Genetics and Epigenetics in Scoliosis Research
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular Genetics and Genetic Diseases".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 508
Special Issue Editors
Interests: quantitative PCR; molecular biology; gene expression; methylation; epigenetics; genetics of id-iopathic scoliosis; epigenetics of idiopathic scoliosis
Interests: microRNA; methylation; epigenetics; genetics of idiopathic scoliosis; epigenetics of idiopathic scoliosis; quantitative PCR; molecular biology; gene expression
Special Issue Information
Dear Colleagues,
We would like to invite you to participate in this Special Issue, entitled "Genetics and Epigenetics in Scoliosis Research".
Scoliosis is the most common structural deformity of the spine in juveniles and adolescents. It is associated with back pain and cosmetic and psychological burdens. Severe scoliosis can lead to pulmonary impairment and functional disability. Scoliosis is a multifactorial disease with an important genetic background, probably modulated by environmental factors, which are claimed to impact its occurrence or progression.
Multiple theories concerning idiopathic scoliosis etiology have been suggested. These concepts cover aberrations in hormonal levels, metabolic factors, connective tissue, skeletal and muscle structure, biomechanical features, neurological mechanisms, molecular, genetic, and epigenetic factors, biochemistry, environment, and lifestyle, as well as possible interrelationships among these aspects.
Growing evidence indicates that addressing the direct effects of genetic and environmental factors might be insufficient for understanding the mechanisms underlying the complexity of human pathologies. Progress in the research of epigenetic mechanisms has improved our understanding of diseases.
Therefore, we welcome manuscripts with a strong genetic and/or epigenetic component, which may include studies of genes linked to scoliosis, and analyses of DNA or RNA.
Dr. Mirosław Andrusiewicz
Dr. Małgorzata Tokłowicz
Guest Editors
Manuscript Submission Information
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Keywords
- congenital and idiopathic scoliosis
- paravertebral muscles
- genetics
- epigenetics
- gene expression modulation
- regulation of development and disease
- epigenetic inheritance
- transcriptional regulation
- noncoding RNA
- DNA modifications
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