Autophagy-Mediated Signalling in Cancer Metastasis and Progression
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 49
Special Issue Editors
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt
Interests: utophagy; AUTACs; apoptosis; antitumor drug development; biochemical and molecular mechanisms of antitumor agents; tumor resistance pathways
Interests: antitumor drugs; biochemical and molecular effects of antitumor drugs and radiation; regulation of senescence arrest; involvement of autophagy in sensitivity and resistance; apoptosis; cisplatin resistance; cancer therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autophagy is a highly conserved catabolic process that facilitates the lysosomal degradation and recycling of damaged proteins, misfolded macromolecules, and dysfunctional organelles. This mechanism is fundamental in maintaining cellular homeostasis and metabolic equilibrium, particularly under conditions of stress. In oncogenesis, however, autophagy assumes a paradoxical role—acting as both a barrier to malignant transformation and a facilitator of tumor survival and progression. Neoplastic cells can exploit autophagic pathways to mitigate the deleterious effects of cytotoxic therapies, thereby promoting therapeutic resistance and tumor persistence. Moreover, dysregulated autophagy has been implicated in various aspects of tumor biology, including enhanced proliferative capacity, metastatic dissemination, and the evasion of immunosurveillance. As such, autophagy represents a double-edged sword in cancer, offering both protective and deleterious potential depending on the context and tumor stage. This Special Issue will be dedicated to elucidating the complex interplay between autophagy and tumorigenesis, with a particular emphasis on its role in therapy resistance, metabolic reprogramming, and metastatic competence. By dissecting the mechanistic underpinnings of autophagy in cancer and exploring novel modulatory strategies, we aim to advance the development of targeted interventions that exploit autophagy as a therapeutic vulnerability in oncology.
Dr. Ahmed M. Elshazly
Prof. Dr. David A. Gewirtz
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- autophagy
- cancer
- resistance
- metastasis
- tumor microenvironment
- immune evasion
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
