The Role of Amyloids in Neurodegenerative Diseases: Current Insights and Future Perspectives
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 310
Special Issue Editors
Interests: Alzheimer’s disease; astrocytes; microglia; amyloid; tau; biomarkers; mouse models; complement system
Special Issue Information
Dear Colleagues,
It is well known that amyloid accumulation is a key pathological hallmark of multiple neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, or amyotrophic lateral sclerosis, among others.
The toxic potential of amyloid aggregation lies in its disruption of cellular processes, induction of oxidative stress, and elicitation of immune responses. Recent insights delve into the interplay of genetic, environmental, and cellular factors in amyloid formation and propagation, enhancing our understanding of disease development and progression. Currently, such critical avenues as amyloid overproduction, impaired clearance mechanisms, and the emergence of cerebral amyloid angiopathy are being explored.
The future holds promise in the pursuit of therapeutic interventions that target amyloid aggregation and clearance. Significant progress has been achieved in clinical trials with anti-amyloid antibodies targeting the removal of amyloid from Alzheimer’s disease patients' brains in the past years. These trials come with potential risks, and some remain skeptical about their success.
This Special Issue welcomes the submission of original research manuscripts or review manuscripts which focus on topics which include, but are not limited to:
- Development of novel amyloidosis animal models and comparison of existing ones;
- Reviews about the past, present, and future of anti-amyloid immunotherapies;
- Studies of the molecular mechanisms involved in amyloid overproduction or amyloid clearance in neurodegenerative diseases;
- Longitudinal studies involving amyloid biomarkers;
- Development of CAA in neurodegenerative disorders;
- Amyloid imaging studies in neurodegenerative disease patients;
- Role of glial cells in amyloid production and clearance.
Dr. Angela Gomez-Arboledas
Dr. Giedre Milinkeviciute
Guest Editors
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Keywords
- neurodegeneration
- amyloid
- anti-amyloid therapies
- microglia
- astrocytes
- glia
- synapses
- biomarkers
- cognitive decline
- animal models
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