Pharmacological Targeting Research of Ion Channels in Inherited and Acquired Diseases
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 289
Special Issue Editor
Interests: pharmacology; ion channels; acquired channelopathies (cancer); pancreatic cancer; rare diseases; genetic channelopathies; non-dystrophic myotonias; drug repurposing; precision medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The human genome contains at least 400 genes encoded for ion channels, pore-forming proteins mediating ion fluxes across membranes. Due to their widespread tissue distribution and their involvement in almost all physiological processes, genetic variation or dysfunction of these proteins are related to the occurrence and development of many inherited and acquired channelopathies. These diseases can range from common to very rare disorders and their severity can be mild, disabling, or life-threatening. Ion channels accordingly constituted promising drug targets and around 18% of FAD-approved drugs for human target ion channels.
This Special Issue seeks papers providing new insights into the investigation of ion channels and their specific subtypes as novel drug targets, ranging from molecular modeling to proof-of-concept animal studies aiming towards translational applications. We hope that interested investigators will share their valuable research on ion channels to exploit the tremendous potential of ion channels as future drug targets.
Dr. Concetta Altamura
Guest Editor
Manuscript Submission Information
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Keywords
- ion channels
- ion channel pharmacology
- genetic channelopathies
- acquired channelopathies
- role of ion channels in cancer
