The Evaluation of Oxidative Stress in Osteoarthritis
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 245
Special Issue Editor
Special Issue Information
Dear Colleagues,
Osteoarthritis (OA) is a degenerative joint disease that involves the cartilage, subchondral bone, synovial membrane and the fibrous articular connective structures. Its arthropathy is characterized by a structural remodeling of the joints, which leads to a decrease in both physical mobility and one’s quality of life. An important factor in the progression of OA is the oxidative stress that sustains a degree of chronic inflammation. Indeed, oxidative stress is defined as a condition of impairment between the production of pro-oxidants, notably reactive oxygen species (ROS), and cellular antioxidant defense capabilities.
The synovial fluid of patients with OA contains significantly reduced levels of antioxidants, such as of superoxide dismutase, glutathione and ascorbate. Additionally, oxidative damage markers, such as lipid peroxides, protein carbonyls and DNA oxidation products, have also been found to be elevated in OA patients, further supporting the role of oxidative stress in the disease’s pathological process.
This Special Issue intends to collect research and review papers that offer new and innovative perspectives upon the evaluation of oxidative stress and the underlying pathogenesis of osteoarthritis. Research efforts made in order to understand the pathogenesis of OA may provide support for the development of new therapeutic strategies, and thus, papers focusing on this area of interest are highly welcomed
Dr. Claudia Diana Gherman
Guest Editor
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Keywords
- osteoarthritis
- oxidative stress
- Reactive Oxygen Species (ROS)
- antioxidants
- biomarkers
- chronic inflammation
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