Role of Endothelial Cells in Cardiovascular Disease—2nd Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 800

Special Issue Editors


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Guest Editor
Department of Emergency Medicine, Internal and Sub-Intensive Medicine, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", 60166 Ancona, Italy
Interests: endothelial cells; atherosclerosis; endothelial progenitor cells; deep vein thrombosis; pulmonary embolism; cardiovascular regenerative medicine; sepsis and septic shock
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Emergency Medicine, Internal and Sub-Intensive Medicine, Azienda Ospedaliero-Universitaria "Ospedali Riuniti", 60166 Ancona, Italy
Interests: endothelial cells; atherosclerosis; endothelial progenitor cells; deep vein thrombosis; pulmonary embolism; cardiovascular regenerative medicine; sepsis and septic shock
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endothelial cells play a pivotal role in cardiovascular system homeostasis through the regulation of several blood vessels’ functions such as vasodilation, inflammation and thrombosis. Cardiovascular diseases represent a leading cause of mortality and morbidity, and endothelial dysfunction contributes to their pathogenesis. Thus, increasing our knowledge of endothelial cells’ pathophysiology in the setting of cardiovascular diseases is strongly advised to prevent and treat important cardiac and vascular pathologies such as hypertension, diabetes, intimal hyperplasia, venous and arterial thrombosis, and heart diseases.

This Special Issue welcomes basic and clinical research, such as original articles and reviews on the following topics:

  • Endothelial cells’ physiology and pathophysiology;
  • Endothelial cells’ role in the pathogenesis of acute and chronic cardiovascular diseases;
  • The role of acute and chronic systemic diseases in the genesis of endothelial dysfunction;
  • New pharmacological approaches for endothelial dysfunction;

Endothelial progenitor cells and cardiovascular regenerative medicine.

Dr. Lorenzo Falsetti
Dr. Vincenzo Zaccone
Guest Editors

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Keywords

  • endothelial cells
  • endothelial dysfunction
  • cardiovascular disease
  • endothelial progenitor cells
  • atherosclerosis
  • thrombosis
  • vessel inflammation
  • regenerative medicine

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Published Papers (1 paper)

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Review

15 pages, 785 KiB  
Review
Systemic Sclerosis: A Key Model of Endothelial Dysfunction
by Vincenzo Zaccone, Lorenzo Falsetti, Silvia Contegiacomo, Serena Cataldi, Devis Benfaremo and Gianluca Moroncini
Biomedicines 2025, 13(7), 1771; https://doi.org/10.3390/biomedicines13071771 - 19 Jul 2025
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Abstract
Systemic sclerosis (SSc) is a heterogeneous disease characterized by vascular alterations, immune dysregulation, and fibrosis. Solid evidence supports the hypothesis that endothelial dysfunction is the key player in SSc vascular injury and a critical factor concurring to the initiation of SSc pathogenesis. This [...] Read more.
Systemic sclerosis (SSc) is a heterogeneous disease characterized by vascular alterations, immune dysregulation, and fibrosis. Solid evidence supports the hypothesis that endothelial dysfunction is the key player in SSc vascular injury and a critical factor concurring to the initiation of SSc pathogenesis. This narrative review reports on persistent endothelial dysfunction, resulting from oxidative stress, autoimmunity, and impaired vascular repair, in the course of SSc, and how it can trigger and sustain fibrotic remodeling of various organs. In this paper, we also analyze the impact on SSc of impaired angiogenesis and vasculogenesis, diminished endothelial progenitor cell function, and endothelial-to-mesenchymal transition, which can collectively disrupt vascular homeostasis and promote myofibroblast activation. These pathologic events underlie the hallmark clinical manifestations, i.e., Raynaud’s phenomenon, digital ulcers, pulmonary arterial hypertension, and scleroderma renal crisis. The review highlights how recognizing SSc as a paradigm of systemic endothelial dysfunction may reframe our understanding of its physiopathology, modify current therapeutic strategies, and unveil new therapeutic targets. Full article
(This article belongs to the Special Issue Role of Endothelial Cells in Cardiovascular Disease—2nd Edition)
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