Multiple Sclerosis: Neuro-Technology and New Approaches for Treatment, Diagnosis and Symptom Monitoring
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 29
Special Issue Editors
Interests: neuropsychology; cognition; multiple sclerosis; parkinson's disease
Interests: multiple sclerosis; demyelinating diseases; neurophysiology; evoked potentials; neuromodulation; non invasive brain stimulation; optical coherence tomography
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The landscape of clinical care and research in multiple sclerosis (MS) is rapidly evolving. Disease-modifying therapies (DMTs) have improved substantially, with recent promising breakthroughs including BTK inhibitors that target progressive MS phenotypes. Non-pharmacological neuromodulation approaches like repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) offer additional promise to enhance the efficacy of both pharmacological and non-pharmacological interventions.
Parallelly, recent digital tools have shown transformative potential for diagnosis and disease monitoring. Wearable sensors enable remote monitoring of a myriad of motor features during real-life activities. Digital cognitive testing platforms demonstrate strong validity while improving accessibility to a wider proportion of patients and facilitating longitudinal, decentralised studies. AI-assisted MRI imaging analysis has shown similar, and in some cases superior, accuracy to human raters. These new technologies can not only improve the ability to diagnose and monitor patients in everyday clinical practice but may also replace conventional endpoints in clinical trials in the future.
This Special Issue invites submissions regarding novel pharmacological treatment strategies and non-invasive neuromodulation (e.g., rTMS, tDCS) in MS. We also welcome submissions exploring biomarkers and digital tools (including, but not limited to, wearable sensors, AI-based imaging analysis, digital cognitive or motor tests, digital patient-reported outcomes) that demonstrate potential to replace conventional MS clinical trial endpoints in the near future.
Reviews are accepted, although the submission of original research studies is encouraged.
Sincerely,
Dr. Michelangelo Dini
Dr. Letizia Leocani
Guest Editors
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Keywords
- multiple sclerosis
- treatment
- neuromodulation
- digital biomarkers
- digital tools
- artificial intelligence
- wearable sensors
- eHealth
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