Biomarkers in Sepsis

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2187

Special Issue Editor


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Guest Editor
Department of Thoracic Medicine, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taipei 105406, Taiwan
Interests: COVID; sepsis; organ injury; endothelial injury

Special Issue Information

Dear Colleagues,

Sepsis imposes a heavy healthcare burden and has a profound impact on survival outcomes worldwide.

Multiple and diverse host response co-exist in sepsis, and knowledge of which dysregulated biological organ system or pathway has been widely investigated. Predicting and evaluating systemic inflammation in sepsis or septic shock are essential to improve outcomes for these patients. Prompt diagnosis, intervention, and risk assessment are essential in treatment of septic patient. Biomarkers may become useful tools to clinicians and ultimately serve as targets for future therapeutic trials in sepsis.  Besides opportunities to improve patient care, employing biomarkers offers a unique opportunity to improve clinical research in patients with sepsis

Dr. Shu-Min Lin
Guest Editor

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Keywords

  • sepsis
  • organ injury
  • biomarkers
  • outcome
  • diagnosis

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Published Papers (1 paper)

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Review

16 pages, 1494 KiB  
Review
Circulating Nucleosomes as a Novel Biomarker for Sepsis: A Scoping Review
by Fuhong Su, Anthony Moreau, Marzia Savi, Michele Salvagno, Filippo Annoni, Lina Zhao, Keliang Xie, Jean-Louis Vincent and Fabio Silvio Taccone
Biomedicines 2024, 12(7), 1385; https://doi.org/10.3390/biomedicines12071385 - 21 Jun 2024
Cited by 5 | Viewed by 1891
Abstract
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing detection methods. This scoping review explores the possible role of nucleosome concentrations in [...] Read more.
Circulating nucleosome levels are commonly elevated in physiological and pathological conditions. Their potential as biomarkers for diagnosing and prognosticating sepsis remains uncertain due, in part, to technical limitations in existing detection methods. This scoping review explores the possible role of nucleosome concentrations in the diagnosis, prognosis, and therapeutic management of sepsis. A comprehensive literature search of the Cochrane and Medline libraries from 1996 to 1 February 2024 identified 110 potentially eligible studies, of which 19 met the inclusion criteria, encompassing a total of 39 SIRS patients, 893 sepsis patients, 280 septic shock patients, 117 other ICU control patients, and 345 healthy volunteers. The enzyme-linked immunosorbent assay [ELISA] was the primary method of nucleosome measurement. Studies consistently reported significant correlations between nucleosome levels and other NET biomarkers. Nucleosome levels were higher in patients with sepsis than in healthy volunteers and associated with disease severity, as indicated by SOFA and APACHE II scores. Non-survivors had higher nucleosome levels than survivors. Circulating nucleosome levels, therefore, show promise as early markers of NETosis in sepsis, with moderate diagnostic accuracy and strong correlations with disease severity and prognosis. However, the available evidence is drawn mainly from single-center, observational studies with small sample sizes and varied detection methods, warranting further investigation. Full article
(This article belongs to the Special Issue Biomarkers in Sepsis)
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