Advances in Heparan Sulfate Biology: Protein Interactions and Therapeutic Implications

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 86

Special Issue Editor

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Guest Editor
Department of Oral Biology, School of Dental Medicine, University at Buffalo, the State University of New York, Buffalo, NY, USA
Interests: heparan sulfate; bone biology; inflammation; glycobiology

Special Issue Information

Dear Colleagues,

Heparan sulfate (HS), an abundant glycosaminoglycan on cell surfaces and the extracellular matrix, exhibits critical regulatory roles for numerous proteins involved in vital biological processes. HS exerts its biological functions by interacting with hundreds of HS-binding proteins, including growth factors, chemokines, cytokines, coagulation factors, enzymes, matrix proteins, etc. The diverse interactions between HS and proteins modulate activities ranging from developmental signaling to homeostatic mechanisms such as coagulation, angiogenesis, bone remodeling, and host defense. Given the importance of HS–protein interactions, targeting these molecular interfaces has recently emerged as a focal point of research with potential therapeutic implications. Current investigative strategies involve the development of specific antibodies and HS oligosaccharide mimetics designed to modulate HS–protein binding, thereby offering opportunities for innovative therapeutic approaches. Additionally, certain natural sulfated carbohydrates, such as those derived from seaweeds and marine organisms that possess a negative charge, may function similarly to heparan sulfate oligosaccharides in this context. This Special Issue aims to highlight the latest advances in our understanding of HS biology, the molecular basis of HS–protein interactions, and the translational potential of targeting these interactions for various pathological conditions.

Dr. Miaomiao Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • heparan sulfate
  • heparin
  • heparanase
  • heparan sulfate-binding protein
  • heparan sulfate oligosaccharides
  • antibody
  • natural sulfated carbohydrates

Published Papers

This special issue is now open for submission.
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