Redirecting T Cells with Chimeric Antigen Receptor (CAR) for the Treatment of Cancer
A special issue of Antibodies (ISSN 2073-4468). This special issue belongs to the section "Antibody-Based Therapeutics".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 306
Special Issue Editors
Interests: tumor microenvironment; tumor immunity; cancer immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
As an effective approach to modulate adaptive immunity, chimeric antigen receptor (CAR) T-cell therapy has revolutionized the paradigm in leukemia treatment, driving an ever-expanding body of basic and clinical research on CAR T cells to treat patients with other types of cancer. The convergence of genome engineering and CAR T-cell therapy technology holds great potential for the generation of a new class of cellular therapeutics. Meanwhile, the clinical application of CAR T-cell therapy remains limited on account of antigen escape and heterogeneity, physical and immune barriers, and on-target off-tumor toxicity. Although several advances have been made in CAR-T therapies, the development of engineered T cells against malignancies remains challenging due to the similarities between normal and tumor cells, the compacted tumor microenvironment, and so on. Understanding the evolution of CAR structure and the generalizable requirements for manufacturing CAR T cells, as well as the interplay between CAR T cells and tumor immunology, will promote the clinical translation of this therapeutic modality.
Dr. Xuyao Zhang
Dr. Xin He
Guest Editors
Manuscript Submission Information
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Keywords
- CAR T cells
- Antigen escape
- Immunosuppressive tumor microenvironment
- Novel tumor target
- Genome engineering
- Cell therapy technology
- Novel strategies
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