Immune Phenomena in Autoimmune Skin Disorders
A special issue of Antibodies (ISSN 2073-4468). This special issue belongs to the section "Antibody-Based Therapeutics".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 758
Editors
Interests: pemphigus; pemphigoid; dermatitis herpetiformis; immunofluorescence; IgG4
Interests: skin immunology; autoimmune blistering diseases; skin barrier; cosmetics; phytotherapy
Special Issue Information
Dear Colleagues,
Autoimmune bullous diseases of the skin and mucous membranes constitute a heterogeneous group of autoimmune mucocutaneous conditions. Pemphigus diseases and pemphigoid diseases are characterized by autoimmunity directed against adhesion molecules, which play a primarily structural role in the mucocutaneous tissues. In dermatitis herpetiformis (DH), enzymes are the target of autoimmunity. An excessive activation of neutrophils is a feature shared by DH and autoinflammatory disorders. The roles of autoantibodies to desmogleins, desmocollins, plakins, BP180, BP230, integrins, p200 (laminin y1 and laminin β4), laminin 332, type VII collagen, epidermal and tissue transglutaminases will be detailed. Antibodies also play a pivotal role in cutaneous pathology in autoimmune connective tissue diseases and vasculitides. Antinuclear antibodies (ANAs) and anti-neutrophil cytoplasmic antibodies (ANCAs) will be discussed. This topic aims to describe recent advances and perspectives on the triggers of autoimmunity, autoantibody turnover and antibody-mediated molecular pathways leading to the clinical manifestations of these diseases. The progress in their diagnosis using imaging techniques and molecular-biochemical methods will be presented. Finally, current and potential treatment regimens aimed at achieving sustained remission of these illnesses will be discussed. Given the immense complexity and extracutaneous pathologies of these conditions, this topic should attract scholars both in fundamental antibody research as well as in clinical research and be of interest to diverse medical community professionals.
Prof. Dr. Marian Dmochowski
Prof. Dr. Justyna Gornowicz-Porowska
Guest Editors
Manuscript Submission Information
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Keywords
- pemphigus
- pemphigoid
- dermatitis herpetiformis
- autoimmune connective tissue diseases
- vasculitides
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