Guiding CAR Cell Therapy by Antibodies
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 August 2018) | Viewed by 465
Special Issue Editor
Interests: therapeutic antibodies; human antibodies and their interactions; vaccine immunogens; molecular engineering; screening and sequencing methodologies; therapeutic proteins; cancer; infectious diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, T cells armed with chimeric antigen receptors (CARs) guided by antibodies have emerged as a promising approach to fight cancer and other diseases. The design of CARs has evolved, but the success of the therapy is contingent upon the combination of robust therapeutics efficacy and enhanced tumor selectivity, with minimal on-target off tumor activity. Several studies have indicated that both the affinity of the antibody and the specificity of its epitope are important components in CAR T cell activity. Other components of the CARs including costimulatory molecules and extracellular spacers are also important. Given the importance of each of these components and the complexity of the T cell receptor interactions and CARs with their targets empirical determination will likely be required to identify the optimal CAR T cell design for any given target. Similarly, natural killer (NK) cells and other cells expressing CARs should be evaluated for efficacy and specificity.
This Special Issue of Antibodies focuses on new research developments of CARs, and especially as related to antibodies.
Prof. Dr. Dimiter S. DimitrovGuest Editor
Manuscript Submission Information
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Keywords
- Chimeric antigen receptors (CARs)
- Cancer and tumor therapy
- Tumor selectivity
- Optimal CAR T cell design
- CAR T cell Activity
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