Tackling Salmonella Resistance in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal System and Management".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 712

Special Issue Editors


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Animal Health Department, Veterinary Faculty, University of Cordoba, Cordoba, Spain
Interests: Salmonella and salmonellosis; food-borne pathogens; antimicrobial resistance; MDR; zoonoses; emergence diseases; One Health
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Guest Editor
Department of Nursing, Pharmacology and Physiotherapy, Pharmacology Area, Faculty of Veterinary, University of Cordoba, Cordoba, Spain
Interests: domestic and wild animal infectious diseases; antimicrobial resistance; genetic analysis; food-borne pathogens; zoonoses
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Food Science and Technology Department, Veterinary Faculty, University of Cordoba, Cordoba, Spain
Interests: predictive microbiology models; quantitative microbial risk assessment; antimicrobial resistance; food shelf-life; biopreservation
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Guest Editor
Veterinary Faculty, Biomedical Sciences Institute, Cardenal Herrera-CEU University, CEU Universities, 46115 Alfara del Patriarca, Valencia, Spain
Interests: antimicrobial resistance; antimicrobial susceptibility testing; veterinary microbiology; companion animals; zoonotic pathogens; biocides; antibiotic alternatives; One health

Special Issue Information

Dear Colleagues,

According to the Centre for Disease Prevention and Control (CDC) and its European counterpart (ECDC), Salmonella is the second most frequently reported zoonotic bacterium, being responsible for foodborne toxigenic infections, and is the most prevalent in human outbreaks. The primary routes of transmission include the consumption of contaminated products of animal origin, such as poultry, pork, or eggs. However, it is important to acknowledge that not only farmed animals but also some companion animals can act as asymptomatic carriers and can contribute to the spread of Salmonella due to their close contact with humans.

The World Health Organization (WHO) has classified it as a “high-priority pathogen”, a designation that includes it in the list of drug-resistant bacteria that pose a serious threat to human health. This is particularly concerning due to the potential for these bacteria to trigger therapeutic failures that can have fatal consequences.

We are pleased to invite you to submit a contribution to the Special Issue, entitled “Tackling Salmonella Resistance in Animals”, which aims to deepen the knowledge on the development of resistance in this bacterium and its implications for public health. We strongly believe that this Special Issue can be an opportunity to gather significant and relevant information on Salmonella resistance in animals, while adopting a One Health approach.

This Special Issue welcomes original research articles and reviews that advance the understanding of antimicrobial resistance in Salmonella spp. Topics of interest include, but are not limited to, the following:

  1. Epidemiological trends and temporal dynamics of antimicrobial resistance (AMR) in Salmonella.
  2. Resistance to critically important antimicrobials (CIAs), particularly third-generation cephalosporins and fluoroquinolones. 
  3. Molecular mechanisms of resistance.
  4. Characterization of presumptive ESBL-, AmpC-, and Carbapenemase-producing Salmonella.
  5. Multidrug resistance (MDR).
  6. Emerging MDR and zoonotic serovars. 
  7. Plasmid diversity and mobile genetic elements.
  8. Biocide resistance.
  9. Biofilm formation by resistant Salmonella.
  10. Whole-genome sequencing (WGS) and other ‘omics’ technologies for AMR Salmonella surveillance systems.  
  11. Novel strategies to combat resistance.

Prof. Dr. Rafael Jesús Astorga
Dr. Angela Galán Relaño
Prof. Dr. Antonio Valero Díaz
Dr. Ana Marco Fuertes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Salmonella resistance
  • antimicrobials
  • MDR
  • antibiotic-resistant genes
  • biocides
  • resistance spread
  • alternative strategies
  • animals
  • One Health

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Published Papers (1 paper)

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Research

17 pages, 616 KB  
Article
Prevalence and Antimicrobial Resistance Patterns of Salmonella in Asymptomatic Horses in Eastern Spain: A One Health Perspective
by María Socorro Simó-Martínez, Ana Marco-Fuertes, Ángela Galán-Relaño, Rafael J. Astorga Márquez, Clara Marin, Antonio Valero Díaz and Santiago Vega
Animals 2025, 15(23), 3413; https://doi.org/10.3390/ani15233413 - 26 Nov 2025
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Abstract
(1) Background: Salmonella are zoonotic pathogens, and rising antimicrobial resistance (AMR) amplifies their public health impact. Asymptomatic horses can act as reservoirs, contributing to environmental contamination and interspecies transmission. This study aimed to estimate the prevalence of Salmonella and characterize AMR patterns [...] Read more.
(1) Background: Salmonella are zoonotic pathogens, and rising antimicrobial resistance (AMR) amplifies their public health impact. Asymptomatic horses can act as reservoirs, contributing to environmental contamination and interspecies transmission. This study aimed to estimate the prevalence of Salmonella and characterize AMR patterns in healthy horses from eastern Spain. (2) Methods: Faecal samples from 95 asymptomatic horses were collected once daily over five consecutive days (475 samples in total) and processed under for Salmonella detection. Epidemiological information was obtained through owner questionnaires, and associations with Salmonella shedding were analyzed using generalized linear models. Antimicrobial susceptibility was assessed by minimum inhibitory concentration assays following the European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria. (3) Results:Salmonella was detected in 25.3% of horses (24/95), with S. Enteritidis, S. Johannesburg, and S. Virchow as the most frequent serotypes. A significant association was observed between proximity of manure storage and bacterial detection (p < 0.001). Among 24 isolates of Salmonella, 88.9% were resistant to at least one antimicrobial, and 50% exhibited multidrug resistance. The highest resistance rates were against sulfamethoxazole and gentamicin, followed by ciprofloxacin and tigecycline. (4) Conclusions: Healthy horses can act as silent carriers of multidrug-resistant Salmonella, highlighting the need for surveillance, strengthened biosecurity, and prudent antimicrobial use within a One Health framework. Full article
(This article belongs to the Special Issue Tackling Salmonella Resistance in Animals)
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