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Adhesives
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Advances in Adhesive Technologies for Dental and Biomedical Applications
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Advances in Adhesive Technologies for Dental and Biomedical Applications

A special issue of Adhesives (ISSN 3042-6081).

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1125

Editors

Dr. Rim Bourgi

E-Mail Website
Guest Editor
Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France
Interests: adhesive dentistry; biomaterials; bleaching agents; bonding; dental photography; digital dentistry; restorative materials
Special Issues, Collections and Topics in MDPI journals
Dr. Carlos Enrique Cuevas Suárez

E-Mail Website1 Website2
Guest Editor
Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca, Mexico
Interests: composite resin; dimethacrylates; photopolymerization; organic matrix; mechanical characterization
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Louis Hardan

E-Mail Website
Guest Editor
Department of Esthetic and Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut, Lebanon
Interests: biomaterials; bonding; bleaching agents; dental photography; digital dentistry; photpolymerization; restorative materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of adhesive technology has experienced remarkable growth, especially in dentistry and biomedical engineering. Contemporary research focuses on optimizing adhesion mechanisms, improving long-term stability, developing bioactive and biomimetic systems, and evaluating interactions with natural tissues or biomaterials. This Special Issue aims to provide a comprehensive platform for the latest scientific advancements related to resin–dentin bonding durability and interface stability, bioactive and antibacterial adhesive formulations, surface treatment methods for 3D-printed or CAD/CAM materials, self-etch, etch-and-rinse, and universal adhesives in clinical dentistry, adhesion to enamel, dentin, ceramics, zirconia, and composite resins, novel adhesion strategies for biomedical device integration, in vitro and in vivo evaluation of bonding systems, and adhesive interface degradation mechanisms and prevention. This Special Issue will contribute significantly to bridging laboratory findings with clinical applications, while promoting the development of next-generation adhesive technologies.

Dr. Rim Bourgi
Dr. Carlos Enrique Cuevas Suárez
Prof. Dr. Louis Hardan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Adhesives is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adhesive dentistry
  • biomaterials
  • dental composites
  • CAD/CAM
  • 3D-printed resins
  • indirect restorations
  • digital workflow
  • luting agents
  • surface treatment
  • restorative dentistry

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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13 pages, 1502 KB  
Article
Comparison of Bond Strength Performance and Adhesive Remnant Patterns of APC™ Plus and APC™ Flash Free Orthodontic Brackets: In Vitro Study on Human Teeth
by Amelie Haring and Bart Vande Vannet
Adhesives 2026, 2(3), 14; https://doi.org/10.3390/adhesives2030014 - 8 Jul 2026
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Abstract
This in vitro study compared the bond strength performance and adhesive remnant characteristics of two metallic orthodontic pre-coated bracket systems: APC™ Plus and APC™ Flash Free. Forty extracted human premolars were randomly allocated to two groups (n = 20). Following enamel etching with [...] Read more.
This in vitro study compared the bond strength performance and adhesive remnant characteristics of two metallic orthodontic pre-coated bracket systems: APC™ Plus and APC™ Flash Free. Forty extracted human premolars were randomly allocated to two groups (n = 20). Following enamel etching with 37% phosphoric acid, brackets were bonded according to the manufacturers’ recommendations. Bond strength testing was performed using a custom-made apparatus in which failure was induced through a progressively increasing load. Because the experimental setup generated a combined loading configuration involving shear, tensile, and bending components, the measured values should be interpreted as comparative bond strength measurements rather than absolute shear bond strength values. Adhesive Remnant Index (ARI) scores were recorded after debonding to evaluate failure patterns. Median bond strength values were 17.75 MPa (IQR: 13.53–21.98) for APC™ Plus and 14.28 MPa (IQR: 9.81–18.74) for APC™ Flash Free. No statistically significant difference was found between groups (Mann–Whitney U test, p = 0.102). In contrast, ARI score distributions differed significantly (Fisher’s exact test, p = 0.001). APC™ Plus brackets predominantly exhibited ARI scores of 2–3, whereas APC™ Flash Free brackets mainly demonstrated ARI scores of 1–2, indicating less adhesive remaining on the enamel surface after debonding. Three enamel fractures were observed in the APC™ Plus group, while none occurred in the APC™ Flash Free group; however, no statistically significant association between bracket type and enamel fracture was identified. Within the limitations of this in vitro study, both bracket systems demonstrated comparable bond strength performance under the experimental conditions investigated. APC™ Flash Free brackets were associated with reduced adhesive remnants on enamel, which may facilitate post-debonding cleanup. Further studies using standardized testing methods and prospective clinical investigations are required to confirm these findings and determine their clinical relevance. Full article
(This article belongs to the Special Issue Advances in Adhesive Technologies for Dental and Biomedical Applications)
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19 pages, 612 KB  
Systematic Review
Digital Clear Aligner Systems as Multifunctional Platforms for Tooth Bleaching: A Systematic Review of Material Performance and Mechanical Implications in Esthetic Dentistry
by Nicolas Nassar, Karim Corbani, Roland Kmeid, Carlos Enrique Cuevas-Suárez, Abigailt Flores-Ledesma and Rim Bourgi
Adhesives 2026, 2(3), 13; https://doi.org/10.3390/adhesives2030013 - 2 Jul 2026
Viewed by 237
Abstract
Background: Clear aligners fabricated via computer-aided design and manufacturing are increasingly used in orthodontics and may also serve as carriers for peroxide-based bleaching agents. However, exposure to bleaching agents may affect the physical and surface properties of aligner polymers, which could influence their [...] Read more.
Background: Clear aligners fabricated via computer-aided design and manufacturing are increasingly used in orthodontics and may also serve as carriers for peroxide-based bleaching agents. However, exposure to bleaching agents may affect the physical and surface properties of aligner polymers, which could influence their clinical performance. Objective: This systematic review aims to evaluate the available evidence on the use of clear aligners as carriers for tooth bleaching agents, with a focus on bleaching efficacy and reported effects on aligner materials based on the identified literature. Methods: A systematic search was conducted in PubMed, Web of Science, Scopus, Scielo, and Embase for studies published up to January 2026. Eligible clinical and in vitro studies investigated bleaching procedures using clear aligners or conventional trays and reported color change outcomes and/or changes in material properties such as hardness, surface integrity, or mechanical performance. Risk of bias was assessed using the Cochrane Risk of Bias tools and standardized criteria for in vitro and clinical studies. Results: Six studies (three clinical and three in vitro) met the inclusion criteria. Clinical evidence indicated that bleaching delivered through clear aligners achieved similar whitening outcomes to conventional tray-based systems. In vitro studies reported changes in surface hardness and mechanical properties of polymer-based aligner materials after peroxide exposure; however, no major structural degradation was observed. Clinical studies were generally at high risk of bias, while in vitro studies showed low to moderate risk. Conclusions: Within the limitations of this systematic review, clear aligners may represent a potential carrier for tooth bleaching agents with outcomes comparable to conventional trays. However, the available evidence is limited and heterogeneous. Well-designed randomized controlled trials are needed to confirm clinical effectiveness and long-term material safety. Full article
(This article belongs to the Special Issue Advances in Adhesive Technologies for Dental and Biomedical Applications)
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