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This page contains a variety of information related to COVID-19 available from MDPI, including journal articles, special issues, and preprints, among others.
The COVID-19 pandemic has posed significant challenges to mental health worldwide, raising the need to identify stable psychological resources that promote sustainable well-being. This longitudinal study examined whether character strengths predict well-being, post-traumatic growth, and mental health over a 13-month period. Participants (N
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The COVID-19 pandemic has posed significant challenges to mental health worldwide, raising the need to identify stable psychological resources that promote sustainable well-being. This longitudinal study examined whether character strengths predict well-being, post-traumatic growth, and mental health over a 13-month period. Participants (N = 146) completed online measures of character strengths, mental health, life satisfaction, affect, and post-traumatic growth at two time points. First, we tested whether a single general factor of character predicted later mental health and whether life satisfaction, affect, and post-traumatic growth mediated this relationship. Then, we repeated this model but with five different character strengths factors as predictors. Results showed that character predicted all mediators and mental health over time, but only the affective components of well-being mediated the relationship between character and mental health, especially positive affect. When looking at the five character strengths factors, although the majority predicted higher well-being and better mental health over time, goodness and interpersonal and fortitude strengths yielded the strongest effects. These findings suggest that character strengths contribute to sustainable well-being by fostering affective resilience in the face of adversity, aligning with the goals of Sustainable Development Goal 3 (Good Health and Well-being).
Full article
Background/Objectives: Mindfulness is a meditative practice that increases levels of awareness and attention. Introducing this practice into the curricula of nursing students could improve the relationship with patients and promote students’ well-being. This scoping review aims to map the literature on mindfulness-based
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Background/Objectives: Mindfulness is a meditative practice that increases levels of awareness and attention. Introducing this practice into the curricula of nursing students could improve the relationship with patients and promote students’ well-being. This scoping review aims to map the literature on mindfulness-based interventions (MBIs) administered to nursing students to promote their psychological well-being. Methods: The review was conducted according to Peters’ framework. PCC eligibility criteria were used. The PCC mnemonic stands for Population (nursing students), Concept (mindfulness-based interventions applied with positive and negative outcomes for psychological well-being), and Context (undergraduate, pre-licensure). The search was conducted in March 2024 by consulting PubMed, ERIC (Ovid), CINAHL (EBSCOhost), PsycINFO (Ovid), and ProQuest databases. Additional sources have been identified from Google Scholar. Results: Of the 763 articles that emerged, 55 were included in the scoping review. The interventions depicted are heterogeneous in terms of content and timing. The most investigated outcomes remain stress and anxiety; self-efficacy and empathy emerge as positive indicators of psychological well-being. In the post-COVID period, there is an increase in the online delivery method. Conclusions: In order to provide guidance for practice and institutional policies, future research could focus on a systematic review that identifies the most appropriate MBIs for the well-being of nursing students. In addition, it would be useful to conduct feasibility studies to introduce structured mindfulness-based practices into the nursing degree programmes, with standardized and adaptable pathways tailored to the needs of different academic realities.
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Background/Objectives: Oral health-related quality of life (OHRQoL) may influence mental health outcomes, yet longitudinal evidence on its association with depression remains limited. This study aimed to examine whether oral health status and OHRQoL are associated with a change in self-reported depression status
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Background/Objectives: Oral health-related quality of life (OHRQoL) may influence mental health outcomes, yet longitudinal evidence on its association with depression remains limited. This study aimed to examine whether oral health status and OHRQoL are associated with a change in self-reported depression status among adults in Japan. Methods: We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), conducted in 2022 and 2023. A total of 15,068 participants aged ≥20 years without depression at baseline were included. Depression status was identified by self-reported measures between the two survey waves. Logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) for change in self-reported depression status in relation to OHRQoL and oral health status, adjusting for sociodemographic and behavioral factors. Results: During follow-up, 218 participants (1.45%) reported a change in self-reported depression status. Poorer OHRQoL was significantly associated with a change in self-reported depression status (OR: 1.018; 95% CI: 1.001–1.036; p = 0.039). Additional risk factors included younger age (OR: 0.974; 95% CI: 0.964–0.985), participation in hobbies and cultural activities (OR: 2.224; 95% CI: 1.498–3.302), habitual use of sleeping pills or anxiolytics (current use OR: 3.512; 95% CI: 2.267–5.442), increased loneliness (OR: 1.217; 95% CI: 1.140–1.299), lower life satisfaction (OR: 0.900; 95% CI: 0.836–0.969), and poor self-rated health (OR: 2.921; 95% CI: 1.810–4.715). Conclusions: Impaired OHRQoL was associated with a change in self-reported depression status, potentially through psychosocial mechanisms. These findings suggest that oral health and OHRQoL may be relevant factors to consider in integrated oral and mental health approaches in clinical practice.
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Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection. Heterologous prime–boost regimens combining distinct vaccine platforms can enhance humoral and cellular immunity through complementary mechanisms. Methods: Using an intramuscular immunization
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Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection. Heterologous prime–boost regimens combining distinct vaccine platforms can enhance humoral and cellular immunity through complementary mechanisms. Methods: Using an intramuscular immunization scheme aligned with clinical vaccination practice, CD-1 mice received homologous or heterologous prime–boost regimens combining a replication-deficient Orf virus (Parapoxvirus orf, ORFV)-based spike vaccine (ORFV-S) with the licensed adjuvanted recombinant protein vaccine VidPrevtyn Beta. Spike-specific humoral and cellular immune responses were assessed. Results: ORFV-S alone induced potent and broad spike-specific IgG responses and achieved the strongest ACE2-binding inhibition across variants of concern. ORFV-S priming followed by VidPrevtyn Beta boosting markedly enhanced the magnitude and cross-variant breadth of antibody responses compared with homologous protein vaccination. Both homologous ORFV-S and heterologous regimens incorporating ORFV-S elicited strong CD4+ and CD8+ T-cell responses, whereas VidPrevtyn Beta alone induced only modest T-cell activity, demonstrating that ORFV-S effectively complements protein-based vaccines. Conclusions: The ORFV-S vector represents a potent vaccine platform capable of inducing broad humoral and cellular immunity. Its use in heterologous prime–boost combinations enhances both antibody magnitude and breadth beyond homologous protein vaccination, supporting its application in vaccination strategies against evolving viral pathogens.
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Background/Objectives The number of children with cardiovascular disease (CVD) risk factors is increasing in the United States. This review summarizes the current knowledge on the relationship between children’s diets and CVD risk factors in children aged 2–18 years. Methods: A systematic literature
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Background/Objectives The number of children with cardiovascular disease (CVD) risk factors is increasing in the United States. This review summarizes the current knowledge on the relationship between children’s diets and CVD risk factors in children aged 2–18 years. Methods: A systematic literature review was conducted using Covidence (PROSPERO registration CRD42024604406) in the three databases PubMed Central, Web of Science, and Embase to include publications published in English between January 2014 and December 2024 that contained the outcome measures total cholesterol, LDL, HDL, triglycerides, and blood pressure. Two independent researchers conducted title, abstract, and full-text screenings; a tiebreaker was used to resolve any conflicts. Risk of bias was assessed using the quality assessment forms included in the Covidence software. Results: Eighty-five studies met the inclusion criteria, and the results were stratified by age group to organize results in a logical manner and increase transparency. Many studies have reported significant relationships, particularly with blood pressure and HDL, but others have found no statistically significant relationships. Conclusions: While a plethora of studies investigating the relationship between diet and CVD risk factors in children are available, the large heterogeneity between the diet factors, diet assessment, outcome measurement methodology, and outcome variable selection varied greatly, affecting the ability to arrive at conclusive results and recommendations. It would be beneficial to develop universally accepted research standards that can be applied to future studies to reduce ambiguity in the understanding of the effect of diet on CVD risk.
Full article
The COVID-19 pandemic had widespread psychological effects, prompting research into long-term impacts on mental health and identity development. This retrospective study examined how pandemic-related stress affected obsessive–compulsive symptoms (OCS) and generalized anxiety symptoms across three timepoints, prior to the pandemic (2019–February 2020), during
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The COVID-19 pandemic had widespread psychological effects, prompting research into long-term impacts on mental health and identity development. This retrospective study examined how pandemic-related stress affected obsessive–compulsive symptoms (OCS) and generalized anxiety symptoms across three timepoints, prior to the pandemic (2019–February 2020), during the height of the pandemic (March 2020–2022), and the present (within the past month), and how changes in these symptoms relates to identity. The sample consisted of undergraduate students (N = 476) who completed an anonymous online survey battery. Indices of psychological “damage” and “recovery” showed although OCS levels returned to baseline in the current period, anxiety levels remained elevated. COVID-related stress predicted higher OCS and anxiety symptoms across timepoints. Greater symptom damage was associated with more identity disturbance, while recovery from anxiety was related to reduced identity disturbance. Recovery from OCS was uniquely related to higher identity consolidation. These findings suggest the psychological toll of the pandemic extends beyond clinical symptoms, impacting foundations of identity. Although some psychological recovery has occurred, lingering anxiety symptoms may continue to affect developmental outcomes. Further research is needed to understand mechanisms that support long-term recovery and identity formation in the wake of large-scale stressors like the COVID-19 pandemic.
Full article
The first webinar in the series, held on 17 April 2020, saw both Prof. Dr. Antoine Flahault, Director of the Institute of Global Health, University of Geneva, Switzerland, and Prof. Dr. Evelyne Bischof, Associate Professor, Shanghai University of Medicine and Health Sciences, Shanghai, China and Research physician, University Hospital of Basel, Basel, Switzerland speak on this topic.
The second webinar in the series, entitled “Coronaviruses: history, replication, innate immune antagonism”, saw Prof. Dr. Susan R. Weiss, Professor of Microbiology, Perelman School of Medicine, University of Pennsylvania speak on this topic.
WEBINAR 3: Could the COVID-19 Crisis be the Opportunity to Make Cities Carbon Neutral, Liveable and Healthy
The third webinar in this series was presented by Prof. Dr. Mark Nieuwenhuijsen, a world leading expert in environmental exposure assessment, epidemiology, and health risk/impact assessment with a strong focus and interest on healthy urban living.
WEBINAR 4: COVID-19 - Global Supply Chains and the SDGs
For the fourth webinar of this series, Prof. Dr. Max Bergman, Dr. Dorothea Schostok and Prof. Dr. Patrick Paul Walsh gave a presentation on Global Supply Chains and the SDGs.
WEBINAR 5: The New Role of Family Physicians in Times of COVID-19
The fifth webinar of the COVID-19 Series saw Prof. Dr. Christos Lionis discuss the new role of family physicians that emerged during the COVID-19 pandemic.
WEBINAR 6: Survey on Symptoms/Signs, Protective Measures, Level of Awareness and Perception Regarding COVID-19 Outbreak among Dentists
In the sixth webinar of this series, Prof. Dr. Guglielmo Campus and Prof. Dr. Maria Grazia present and discuss the risk and the preventions that can and should be taken by dentists during this pandemic.
WEBINAR 7: Living with COVID-19: An Early Intervention Therapeutic Strategy to Control the Pandemic
The seventh webinar of the COVID-19 series, Dr. Hamid Merchant discussed the different therapeutic strategies that can be adopted in the early stages of the infection.
WEBINAR 8: Impact of COVID-19 on Routine Immunization, Reproduction and Pregnancy Outcome
For the eighth COVID-19 webinar, Prof. Dr. Jon Øyvind Odland discussed the effect that COVID-19 seems to have on pregnant women; whereas Prof. Dr. Giovanni Gabutti discussed the role of routine immunization as a way of fighting COVID-19.
