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Nutrients
Volume 12
Issue 3
10.3390/nu12030845
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Article

The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men

by
Robert W. Davies
1,2,*,†,
Joseph J. Bass
1,2,3,†,
Brian P. Carson
1,2,4,
Catherine Norton
1,2,4,
Marta Kozior
1,2,
Daniel J. Wilkinson
3,
Matthew S. Brook
3,
Philip J. Atherton
3,
Ken Smith
3 and
Philip M. Jakeman
1,2,4
1
Department of Physical Education & Sport Sciences, University of Limerick, V94 T9PX Limerick, Ireland
2
Food for Health Ireland (FHI), Centre for Interventions in Infection, Inflammation & Immunity, University of Limerick, V94 T9PX Limerick, Ireland
3
Medical Research Council (MRC) and Arthritis Research United Kingdom (ARUK) Centre for Musculoskeletal Aging Research and National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, UK
4
Health Research Institute (HRI), University of Limerick, V94 T9PX Ireland, Ireland
*
Author to whom correspondence should be addressed.
†
These authors are co-first author.
Nutrients 2020, 12(3), 845; https://doi.org/10.3390/nu12030845
Submission received: 27 February 2020 / Revised: 18 March 2020 / Accepted: 20 March 2020 / Published: 21 March 2020
(This article belongs to the Special Issue The Regulation of Human Skeletal Muscle Metabolism by Nutrients across the Lifespan)
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Abstract

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind randomised parallel group design, 16 resistance-trained men aged 18 to 35 years completed a 7-d RT protocol, consisting of three lower-body RT sessions on non-consecutive days. Participants consumed a controlled diet (146 kJ·kg−1·d−1, 1.7 g·kg−1·d−1 protein) with either a whey protein supplement or an isonitrogenous control (0.33 g·kg−1·d−1 protein). To measure myoPS, 400 ml of deuterium oxide (D2O) (70 atom %) was ingested the day prior to starting the study and m. vastus lateralis biopsies were taken before and after RT-intervention. Myofibrillar fractional synthetic rate (myoFSR) was calculated via deuterium labelling of myofibrillar-bound alanine, measured by gas chromatography-pyrolysis-isotope ratio mass spectrometry (GC-Pyr-IRMS). Muscle recovery parameters (i.e., countermovement jump height, isometric-squat force, muscle soreness and serum creatine kinase) were assessed daily. Results: MyoFSR PRE was 1.6 (0.2) %∙d−1 (mean (SD)). Whey protein supplementation had no effect on myoFSR (p = 0.771) or any recovery parameter (p = 0.390–0.989). Conclusions: Over an intense 7-d RT protocol, 0.33 g·kg−1·d−1 of supplemental whey protein does not enhance day-to-day measures of myoPS or postexercise recovery in resistance-trained men.
Keywords: dietary protein; deuterium oxide; exercise performance; humans; skeletal muscle; whey protein. dietary protein; deuterium oxide; exercise performance; humans; skeletal muscle; whey protein.

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MDPI and ACS Style

Davies, R.W.; Bass, J.J.; Carson, B.P.; Norton, C.; Kozior, M.; Wilkinson, D.J.; Brook, M.S.; Atherton, P.J.; Smith, K.; Jakeman, P.M. The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients 2020, 12, 845. https://doi.org/10.3390/nu12030845

AMA Style

Davies RW, Bass JJ, Carson BP, Norton C, Kozior M, Wilkinson DJ, Brook MS, Atherton PJ, Smith K, Jakeman PM. The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients. 2020; 12(3):845. https://doi.org/10.3390/nu12030845

Chicago/Turabian Style

Davies, Robert W., Joseph J. Bass, Brian P. Carson, Catherine Norton, Marta Kozior, Daniel J. Wilkinson, Matthew S. Brook, Philip J. Atherton, Ken Smith, and Philip M. Jakeman. 2020. "The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men" Nutrients 12, no. 3: 845. https://doi.org/10.3390/nu12030845

APA Style

Davies, R. W., Bass, J. J., Carson, B. P., Norton, C., Kozior, M., Wilkinson, D. J., Brook, M. S., Atherton, P. J., Smith, K., & Jakeman, P. M. (2020). The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men. Nutrients, 12(3), 845. https://doi.org/10.3390/nu12030845

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