1 h Postload Glycemia Is Associated with Low Endogenous Secretory Receptor for Advanced Glycation End Product Levels and Early Markers of Cardiovascular Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Biochemical Analyses
2.3. Carotid Ultrasound Examination
2.4. Arterial Stiffness Evaluation
2.4.1. Pulse Wave Velocity
2.4.2. Pulse Wave Analysis
2.5. Statistical Analyses
3. Results
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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NGT 1 h <155 mg/dL (n = 123) | NGT 1 h ≥155 mg/dL (n = 84) | IFG/IGT (n = 75) | |
---|---|---|---|
Age (year) | 45 ± 10.2 | 47.5 ± 10 * | 49.5 ± 7.8 *# |
BMI (Kg/m2) | 29.5 ± 5 | 29.2 ± 4 | 29.8 ± 6.1 |
Waist circumference (cm) | 99.9 ± 11.7 | 100 ± 10.8 | 98.3 ± 9.6 |
Fasting glucose (mg/dL) | 86.4 ± 8.6 | 90.5 ± 8.6 * | 99.4 ± 14 *# |
1 h postload glucose (mg/dL) | 121.3 ± 21.1 | 176 ± 22.4 * | 187.6 ± 35.4 |
2 h postload glucose (mg/dL) | 105.3 ± 22 | 119 ± 21.4 * | 168.4 ± 22.4 |
HbA1c (%) | 5.6 ± 0.3 | 5.8 ± 0.38 * | 6.0 ± 0.31 |
Fasting insulin (μU/mL) | 7.2 ± 3.6 | 9 ± 6.5 | 10.8 ± 5.6 |
Total cholesterol (mg/dL) | 192.2 ± 36.7 | 197.4 ± 42.1 | 199.4 ± 40.4 |
HDL cholesterol (mg/dL) | 49.1 ± 11.4 | 44 ± 12.3 * | 43.1 ± 11.8 * |
Triglycerides (mg/dL) | 86 (66–122) | 100 (76–137) | 125.5 (85–173) |
LDL cholesterol (mg/dL) | 124.1 ± 32.4 | 128.4 ± 41.1 * | 125.2 ± 33.5 |
Systolic BP (mmHg) | 118.2 ± 15.6 | 121 ± 13.5 | 123.9 ± 14.2 * |
Diastolic BP (mmHg) | 73.2 ± 11 | 74.4 ± 10.6 | 75.1 ± 10.4 |
HOMA-IR | 1.55 ± 0.84 | 2.09 ± 1.55 * | 2.3 ± 1.5 *# |
Hypertension | 16% | 26% | 31% |
ACE inhibitors/ARB | 50% | 50% | 52% |
Calcium channel blockers | 20% | 22% | 22% |
Beta blockers | 5% | 9% | 8% |
Thiazide diuretics | 15% | 5% | 8% |
No therapy | 10% | 14% | 12% |
Statin therapy | 18% | 20% | 22% |
Active smokers | 30% | 26% | 34% |
Sex (M/F) | 41/82 | 41/42 | 35/40 |
NGT 1 h <155 mg/dL (n = 123) | NGT 1 h ≥155 mg/dL (n = 84) | IFG/IGT (n = 75) | |
---|---|---|---|
IMT (mm) | 0.69 (0.56–0.71) | 0.78 (0.68–0.83) * | 0.83 (0.71–0.92) *# |
PWV (cm/sec) | 7.22 ± 1.6 | 7.7 ± 1.4 * | 8.2 ± 1.6 *# |
Aug P (mmHg) | 9.2 ± 6.5 | 11.6 ± 6.1 * | 12.7 ± 6.1 * |
Aug I (%) | 25.2 ± 12 | 28.6 ± 11.7 * | 30.6 ± 11.7 * |
SEVR (%) | 162 ± 27.7 | 158 ± 30.8 | 158.2 ± 32.3 |
Coefficient β | p-Value | |
---|---|---|
esRAGE | ||
Model 1 * | ||
Systolic BP | 0.29 | 0.03 |
Model 2 ** | ||
HbA1c | −0.18 | 0.01 |
Model 3 *** | ||
HbA1c | −0.27 | 0.05 |
hs-CRP | −0.35 | 0.04 |
IMT | ||
Model 1 * | ||
age | 0.52 | 0.001 |
Model 2 ** | ||
age | 0.51 | 0.001 |
HbA1c | 0.2 | 0.05 |
Model 3 *** | ||
age | 0.51 | 0.001 |
HbA1c | 0.35 | 0.04 |
esRAGE | −0.21 | 0.005 |
PWV | ||
Model 1 * | ||
age | 0.25 | 0.006 |
Systolic BP | 2.4 | 0.01 |
HDL | −2.5 | 0.01 |
Model 2 ** | ||
age | 0.16 | 0.04 |
Systolic BP | 0.31 | 0.001 |
Model 3 *** | ||
S100A12 | 0.31 | 0.04 |
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Di Pino, A.; Urbano, F.; Scicali, R.; Di Mauro, S.; Filippello, A.; Scamporrino, A.; Piro, S.; Purrello, F.; Rabuazzo, A.M. 1 h Postload Glycemia Is Associated with Low Endogenous Secretory Receptor for Advanced Glycation End Product Levels and Early Markers of Cardiovascular Disease. Cells 2019, 8, 910. https://doi.org/10.3390/cells8080910
Di Pino A, Urbano F, Scicali R, Di Mauro S, Filippello A, Scamporrino A, Piro S, Purrello F, Rabuazzo AM. 1 h Postload Glycemia Is Associated with Low Endogenous Secretory Receptor for Advanced Glycation End Product Levels and Early Markers of Cardiovascular Disease. Cells. 2019; 8(8):910. https://doi.org/10.3390/cells8080910
Chicago/Turabian StyleDi Pino, Antonino, Francesca Urbano, Roberto Scicali, Stefania Di Mauro, Agnese Filippello, Alessandra Scamporrino, Salvatore Piro, Francesco Purrello, and Agata Maria Rabuazzo. 2019. "1 h Postload Glycemia Is Associated with Low Endogenous Secretory Receptor for Advanced Glycation End Product Levels and Early Markers of Cardiovascular Disease" Cells 8, no. 8: 910. https://doi.org/10.3390/cells8080910