Crosstalk between Oxidative Stress and Tauopathy

Haque, Md. Mamunul; Murale, Dhiraj P.; Kim, Yun Kyung; Lee, Jun-Seok

doi:10.3390/ijms20081959

Open AccessReview

Crosstalk between Oxidative Stress and Tauopathy

¹

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea

²

Bio-Med Division, KIST-School UST, Seoul 02792, Korea

³

Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Brain Science Institute (BSI), Korea Institute of Science and Technology (KIST), Seoul 02792, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2019, 20(8), 1959; https://doi.org/10.3390/ijms20081959

Submission received: 2 April 2019 / Revised: 16 April 2019 / Accepted: 19 April 2019 / Published: 22 April 2019

(This article belongs to the Special Issue Oxidative Stress in Neurodegenerative Diseases: Amyloid, Extracellular Vesicles and Biomarkers)

Download

Browse Figures

Review Reports Versions Notes

Abstract

Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients’ brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy.

Keywords: oxidative stress; reactive oxygen species; tauopathy

Graphical Abstract

Share and Cite

MDPI and ACS Style

Haque, M.M.; Murale, D.P.; Kim, Y.K.; Lee, J.-S. Crosstalk between Oxidative Stress and Tauopathy. Int. J. Mol. Sci. 2019, 20, 1959. https://doi.org/10.3390/ijms20081959

AMA Style

Haque MM, Murale DP, Kim YK, Lee J-S. Crosstalk between Oxidative Stress and Tauopathy. International Journal of Molecular Sciences. 2019; 20(8):1959. https://doi.org/10.3390/ijms20081959

Chicago/Turabian Style

Haque, Md. Mamunul, Dhiraj P. Murale, Yun Kyung Kim, and Jun-Seok Lee. 2019. "Crosstalk between Oxidative Stress and Tauopathy" International Journal of Molecular Sciences 20, no. 8: 1959. https://doi.org/10.3390/ijms20081959

APA Style

Haque, M. M., Murale, D. P., Kim, Y. K., & Lee, J.-S. (2019). Crosstalk between Oxidative Stress and Tauopathy. International Journal of Molecular Sciences, 20(8), 1959. https://doi.org/10.3390/ijms20081959

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Crosstalk between Oxidative Stress and Tauopathy

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI