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Targets, Volume 1, Issue 1

2023 September - 6 articles

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Articles (6)

  • Article
  • Open Access
1 Citations
3,292 Views
16 Pages

12 September 2023

RNA interference (RNAi) therapy is a promising approach for cancer therapy. However, due to the weak binding affinity between a carrier and small interference RNA (siRNA) and complicated tumor environment, efficient loading and release of siRNA still...

  • Article
  • Open Access
2 Citations
3,410 Views
15 Pages

The Synthesis of BODIPY-TKI Conjugates and Investigation of Their Ability to Target the Epidermal Growth Factor Receptor

  • Simran Dhingra,
  • Prajesh Shrestha,
  • Arpan Chowdhury,
  • Zehua Zhou,
  • Seetharama D. Jois and
  • Maria da Graça H. Vicente

30 August 2023

A near-IR BODIPY was covalently conjugated via its isothiocyanate groups to one or two Erlotinib molecules, a known tyrosine kinase inhibitor (TKI), via triethylene glycol spacers, to produce two novel BODIPY-monoTKI and BODIPY-diTKI conjugates. The...

  • Article
  • Open Access
5 Citations
2,853 Views
14 Pages

An Activatable Nanoscintillator Probe for Detecting Telomerase Activity and Screening Inhibitors In Vivo

  • Baoliu Chen,
  • Junduan Dai,
  • Sijie Song,
  • Xianzhe Tang,
  • Yuheng Guo,
  • Ting Wu,
  • Mengnan Wu,
  • Chaojie Hao,
  • Xiaofeng Cheng and
  • Huanghao Yang
  • + 3 authors

14 June 2023

Telomerase represents an essential molecular machinery for tumor occurrence and progression and a potential therapeutic target for cancer treatment. Sensitive and reliable analysis of telomerase activity is of significant importance for the diagnosis...

  • Review
  • Open Access
2 Citations
4,982 Views
29 Pages

Fluorescent Imaging Agents for Brain Diseases

  • Feida Che,
  • Xiaoming Zhao,
  • Xin Wang,
  • Ping Li and
  • Bo Tang

1 June 2023

The onset of brain diseases has a terrible impact on people’s lives, including brain tumors, Alzheimer’s disease, Parkinson’s disease, depression, and schizophrenia. Thus, the diagnosis and treatment of various brain disorders have...

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Targets - ISSN 2813-3137