Oleaginous Red Yeasts: Concomitant Producers of Triacylglycerides and Carotenoids

Round 1

Reviewer 1 Report

This review seems to me quite interesting, concise and well-written. The number and the choice of references seems to me quite relevant. The structure and the organization of the paper is also quite clear.

On the other hand, I would rather improve the style and the visual of all the figures. They appear to me quite “old-fashion” regarding all the tools that are available now. The visual quality of the manuscript would probably be well-improved using more “modern” styles for metabolic pathway and compartmentation views.

Author Response

Comment) This review seems to me quite interesting, concise and well-written. The number and the choice of references seems to me quite relevant. The structure and the organization of the paper is also quite clear. On the other hand, I would rather improve the style and the visual of all the figures. They appear to me quite “old-fashion” regarding all the tools that are available now. The visual quality of the manuscript would probably be well-improved using more “modern” styles for metabolic pathway and compartmentation views.

Response) We have revised the figures as requested. Figure 2 in the original manuscript has been deleted. This was the mevalonate-carotenoid pathway, which is a very common pathway that doesn’t need to be repeated.

Reviewer 2 Report

Referees Comments

on the manuscript entitled "Oleaginous Red Yeasts: Concomitant Producers of Triacyl-glycerides and Carotenoids” for Encyclopedia

This is a useful review for those who want to get to know the status of triacyl-glycerides and carotenoids production by oleaginous red yeasts. It is well documented and easy to read. The presented manuscript can be published in the Encyclopedia, however the section about the generation of acetyl-CoA and Figure 1 needs to be supplemented with acetyl-CoA synthesis via glyoxylate cycle.

Author Response

Comment) This is a useful review for those who want to get to know the status of triacyl-glycerides and carotenoids production by oleaginous red yeasts. It is well documented and easy to read. The presented manuscript can be published in the Encyclopedia, however the section about the generation of acetyl-CoA and Figure 1 needs to be supplemented with acetyl-CoA synthesis via glyoxylate cycle.

Response) Figure 1 has been revised, but not as Reviewer 2 requested. Reviewer 2 wanted Figure 1 supplemented with Acetyl-CoA synthesis via glyoxylate cycle, but the glyoxylate cycle uses Acetyl-CoA and supplies Succinate to the TCA. It does not synthesize acetyl CoA.

Round 2

Reviewer 2 Report

accept without any corrections