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BioChem, Volume 3, Issue 2

June 2023 - 3 articles

Cover Story: Flavan-3-ol derivatives are polyphenolic compounds with multifunctional properties. We found that epicatechin-3,5-di-O-gallate and its fluorinated derivatives exhibited high toxicity against HeLa and A549 cells. The addition of fluorinated derivatives increased the amount of intracellular mitochondrial superoxide, abolished the membrane potential of mitochondria, and, interestingly, formed granular aggregates containing mitochondria. When the level of LC3-II, a marker of autophagy induction, was confirmed, it suggested that the addition of fluorinated compounds promoted autophagy. These results suggest that the novel highly cytotoxic fluorinated flavan-3-ol compound synthesized in this study promotes autophagy and induces cell death by triggering mitochondrial aggregation. View this paper

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Communication

11 Citations

13,660 Views

11 Pages

DMSO Alleviates LPS-Induced Inflammatory Responses in RAW264.7 Macrophages by Inhibiting NF-κB and MAPK Activation

Hyunju Han,
Jin-Kyu Kang,
Keun Jae Ahn and
Chang-Gu Hyun

BioChem2023, 3(2), 91-101;https://doi.org/10.3390/biochem3020007

14 June 2023

Dimethyl sulfoxide (DMSO), an amphipathic molecule composed of one highly polar sulfinyl group and two nonpolar methyl groups, is considered an excellent solvent due to its capability to dissolve many polar and nonpolar compounds. Therefore, DMSO is...

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Article

3 Citations

3,554 Views

13 Pages

Nitric Oxide Production from Nitrite plus Ascorbate during Ischemia upon Hippocampal Glutamate NMDA Receptor Stimulation

Carla Nunes and
João Laranjinha

BioChem2023, 3(2), 78-90;https://doi.org/10.3390/biochem3020006

3 May 2023

Nitric oxide (•NO), a diffusible free radical, is an intercellular messenger, playing a crucial role in several key brain physiological processes, including in neurovascular coupling (NVC). In the brain, glutamatergic activation of the neuronal...

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Article

1 Citations

2,830 Views

17 Pages

Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria

Ryo Doge,
Yuki Nishino and
Akiko Saito

BioChem2023, 3(2), 61-77;https://doi.org/10.3390/biochem3020005

17 April 2023

Flavan-3-ol derivatives are polyphenolic compounds with multifunctional properties. One of the flavan-3-ol derivatives, green tea catechin epigallocatechin gallate, is known to have anticancer activity as one of its multifunctional properties. We hav...

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BioChem - ISSN 2673-6411

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