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Review

B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature

by
Gioia Di Stefano
1,2,
Francesca Magnoli
3,
Massimo Granai
4,
Federico Vittone
5,
Raffaella Santi
1,
Domenico Ferrara
2,
Emanuela Boveri
6,
Ada M. Florena
7,
Falko Fend
4,
Elena Sabattini
8,
Marco Paulli
9,
Maurilio Ponzoni
10,11,
Stefano Lazzi
2,
Stefano A. Pileri
12,
Lorenzo Leoncini
2,* and
the Italian Group of Hematopathology
†
1
Pathology Section, Department of Health Sciences, University of Florence, 50100 Florence, Italy
2
Section of Pathology, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy
3
Department of Pathology, University Hospital, 21100 Varese, Italy
4
Institute of Pathology and Neuropathology, Tübingen University Hospital and Comprehensive Cancer Center Tübingen-Stuttgart, 72070 Tübingen, Germany
5
Department of Pathology, Ivrea Hospital ASLTO4, Piazza Credenza 2, 10015 Ivrea, Italy
6
Department of Pathology, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy
7
Anatomic Pathology, Department of Sciences for the Promotion of Health and Mother and Child Care, University of Palermo, 90127 Palermo, Italy
8
Haematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
9
Unit of Anatomic Pathology, Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo and Università degli Studi di Pavia, 27100 Pavia, Italy
10
Faculty of Medicine, Vita-Salute San Raffaele University, 20100 Milan, Italy
11
Pathology Unit, Ospedale San Raffaele Scientific Institute, 20100 Milan, Italy
12
Division of Hematopathology, European Institute of Oncology, IRCCS, 20100 Milan, Italy
 
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*
Author to whom correspondence should be addressed.
†
“Italian Group of Hematopathology” (GIE) is the group of italian pathologist interested in Hematopathology in the Italian society of Pathology (SIAPEC) and organizing several tutorial and WS for the society.
Hemato 2022, 3(4), 634-649; https://doi.org/10.3390/hemato3040043
Submission received: 31 August 2022 / Revised: 25 September 2022 / Accepted: 26 September 2022 / Published: 3 October 2022
(This article belongs to the Special Issue Classification of Lymphomas and Hematological Neoplasia in the Era of Genomic Research: A Themed Issue in Honor of Dr. Elaine S. Jaffe)
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Abstract

Lymphoproliferative neoplasms of uncertain biological significance are increasingly encountered due to widespread usage of immunophenotypic and molecular techniques. Considering that clearer biological criteria and patient management have been established for B-cell lymphoproliferative diseases of undetermined significance occurring in the peripheral blood, many issues are still obscure for early lesions detected in lymphoid tissues. Regardless that some categories of lymphoproliferative neoplasms of uncertain biological significance have been recognized by the 4th edition of the WHO, other anecdotal early lymphoproliferative lesions still remain fully undefined. Some early lesions frequently originate from the germinal center, including atypical germinal centers BCL2-negative, an early pattern of large B-cell lymphoma with IRF4 rearrangement, and “in situ” high-grade B lymphomas. Moreover, other early lymphoproliferative lesions arise outside the germinal center and include those developing within the setting of monocytoid B-cell hyperplasia, but they also can be directly or indirectly associated with chronic inflammations. This review aims to summarize the concepts discussed during the IV Workshop organized by the Italian Group of Hematopathology, focus on the state-of-the-art on B-cell lymphoproliferative neoplasms of uncertain biological significance, and offer operative insights to pathologists and clinicians in routine diagnostics.
Keywords: lymphoproliferative neoplasms of uncertain biological significance; monoclonal B-cell lymphocytosis; “in situ” follicular neoplasia; “in situ” mantle cell neoplasia; atypical germinal centers; large B-cell lymphoma with IRF4 rearrangement; “in situ” high-grade B lymphomas; non-Hodgkin lymphoma; Hodgkin lymphoma lymphoproliferative neoplasms of uncertain biological significance; monoclonal B-cell lymphocytosis; “in situ” follicular neoplasia; “in situ” mantle cell neoplasia; atypical germinal centers; large B-cell lymphoma with IRF4 rearrangement; “in situ” high-grade B lymphomas; non-Hodgkin lymphoma; Hodgkin lymphoma

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MDPI and ACS Style

Di Stefano, G.; Magnoli, F.; Granai, M.; Vittone, F.; Santi, R.; Ferrara, D.; Boveri, E.; Florena, A.M.; Fend, F.; Sabattini, E.; et al. B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature. Hemato 2022, 3, 634-649. https://doi.org/10.3390/hemato3040043

AMA Style

Di Stefano G, Magnoli F, Granai M, Vittone F, Santi R, Ferrara D, Boveri E, Florena AM, Fend F, Sabattini E, et al. B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature. Hemato. 2022; 3(4):634-649. https://doi.org/10.3390/hemato3040043

Chicago/Turabian Style

Di Stefano, Gioia, Francesca Magnoli, Massimo Granai, Federico Vittone, Raffaella Santi, Domenico Ferrara, Emanuela Boveri, Ada M. Florena, Falko Fend, Elena Sabattini, and et al. 2022. "B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature" Hemato 3, no. 4: 634-649. https://doi.org/10.3390/hemato3040043

APA Style

Di Stefano, G., Magnoli, F., Granai, M., Vittone, F., Santi, R., Ferrara, D., Boveri, E., Florena, A. M., Fend, F., Sabattini, E., Paulli, M., Ponzoni, M., Lazzi, S., Pileri, S. A., Leoncini, L., & the Italian Group of Hematopathology. (2022). B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature. Hemato, 3(4), 634-649. https://doi.org/10.3390/hemato3040043

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