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Journal of Molecular Pathology, Volume 3, Issue 2

June 2022 - 4 articles

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Articles (4)

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Article

3 Citations

5,268 Views

11 Pages

Use of the Biocartis Idylla™ Platform for the Detection of Epidermal Growth Factor Receptor, BRAF and KRAS Proto-Oncogene Mutations in Liquid-Based Cytology Specimens from Patients with Non-Small Cell Lung Carcinoma and Pancreatic Adenocarcinoma

Leonie Wheeldon,
Mary Jones,
Ben Probyn,
Dushyant Shetty and
James Garvican

J. Mol. Pathol.2022, 3(2), 104-114;https://doi.org/10.3390/jmp3020010

14 May 2022

The study aimed to demonstrate rapid and effective molecular testing on liquid-based cytology (LBC) samples for EGFR, KRAS and BRAF mutations using the Biocartis Idylla™. Rapid on-site evaluation (ROSE) LBC samples for patients with non-small c...

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Review

16 Citations

4,780 Views

16 Pages

Micro-RNA in Cholangiocarcinoma: Implications for Diagnosis, Prognosis, and Therapy

Anna Barbato,
Fabiola Piscopo,
Massimiliano Salati,
Luca Reggiani-Bonetti,
Brunella Franco and
Pietro Carotenuto

J. Mol. Pathol.2022, 3(2), 88-103;https://doi.org/10.3390/jmp3020009

9 May 2022

Bile-duct cancers (BDC) are a group of solid tumors arising from the biliary tree. Despite their classification as rare cancers, the incidence of BDC is increasing worldwide. Poor prognosis is a common feature of this type of cancer and is mainly det...

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Article

3 Citations

3,289 Views

10 Pages

Molecular Diagnostics of Lung Cancer in Serous Effusion Samples

Jana Fassunke,
Reinhard Büttner and
Marianne Engels

J. Mol. Pathol.2022, 3(2), 78-87;https://doi.org/10.3390/jmp3020008

12 April 2022

For molecular diagnostics of lung cancer samples, often only a small amount of material is available. The ever-increasing number of biomarker testing is in contrast to the amount of material obtained. In that case, cytological specimens, such as sero...

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Case Report

1 Citations

3,161 Views

10 Pages

Prometastatic CXCR4 and Histone Methyltransferase EZH2 Are Upregulated in SMARCB1/INI1-Deficient and TP53-Mutated Poorly Differentiated Chordoma

Albina Joldoshova,
Shaimaa Elzamly,
Robert Brown and
Jamie Buryanek

J. Mol. Pathol.2022, 3(2), 68-77;https://doi.org/10.3390/jmp3020007

2 April 2022

Background: Chordoma is a rare tumor most commonly arising in the sacrococcygeal region from notochord remnants. Usually, these tumors are locally invasive and recurrent, and they have a 5–43% ability to metastasize. A newly-described aggressive vari...

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