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Engineering Proceedings
Volume 37
Issue 1
10.3390/ECP2023-14737
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Proceeding Paper

Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp †

by
Nicola Pinna
1,2,*,
Francesca Blasi
1 and
Aurélie Schoubben
2
1
Section of Food Sciences and Nutrition, Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy
2
Section of Pharmaceutical Chemistry and Technology, Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Electronic Conference on Processes: Process Engineering–Current State and Future Trends (ECP 2023), 17–31 May 2023; Available online: https://ecp2023.sciforum.net/.
Eng. Proc. 2023, 37(1), 5; https://doi.org/10.3390/ECP2023-14737
Published: 30 May 2023
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Processes: Process Engineering—Current State and Future Trends)
Versions Notes

Abstract

This work aimed to optimize the production of Solid Lipid Nanoparticles (SLN) for the future encapsulation of carotenoid-rich extracts obtained from pumpkin (Cucurbita moschata) pulp by ultrasound-assisted extraction. The extracts were characterized by in vitro spectrophotometric assays and by high-performance liquid chromatography, coupled with a diode array detector. Hot high-pressure homogenization was the method selected for SLN production, and β-carotene was used as a model molecule for optimization. This choice was supported by chemical–analytical characterization, which identified β-carotene as the main carotenoid of the pumpkin extracts. SLN loaded with 1% β-carotene showed dimensions compatible with increased intestinal absorption. Furthermore, antioxidant assay results showed that the technological process did not alter the antioxidant capacity of β-carotene.
Keywords: nanoencapsulation; binary mixture; unconventional extraction; pumpkin; nanoparticles; antioxidant properties; β-carotene; pharmaceutical technology nanoencapsulation; binary mixture; unconventional extraction; pumpkin; nanoparticles; antioxidant properties; β-carotene; pharmaceutical technology

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MDPI and ACS Style

Pinna, N.; Blasi, F.; Schoubben, A. Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp. Eng. Proc. 2023, 37, 5. https://doi.org/10.3390/ECP2023-14737

AMA Style

Pinna N, Blasi F, Schoubben A. Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp. Engineering Proceedings. 2023; 37(1):5. https://doi.org/10.3390/ECP2023-14737

Chicago/Turabian Style

Pinna, Nicola, Francesca Blasi, and Aurélie Schoubben. 2023. "Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp" Engineering Proceedings 37, no. 1: 5. https://doi.org/10.3390/ECP2023-14737

APA Style

Pinna, N., Blasi, F., & Schoubben, A. (2023). Optimization of Solid Lipid Nanoparticles for the Encapsulation of Carotenoids from Cucurbita moschata Pulp. Engineering Proceedings, 37(1), 5. https://doi.org/10.3390/ECP2023-14737

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