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Diabetology
Volume 7
Issue 2
10.3390/diabetology7020031
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Article

Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice

by
Espiridión Ramos-Martínez
1,*,
Ramcés Falfán-Valencia
2,
Gloria Pérez-Rubio
2,
Francisco Javier García-Vázquez
3,
Jorge Rojas-Serrano
4,
Anayántzin Paulina Heredia-Antúnez
5,
Gerardo Aristi-Urista
6 and
Anahí Chavarria-Krauser
1
1
Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México C.P. 06726, Mexico
2
Pneumogenomics Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, México City C.P. 14080, Mexico
3
Laboratorio de Inmunogenética Molecular, Departamento de Análisis Clínicos y Estudios Especiales, Instituto Nacional de Pediatría, Ciudad de México C.P. 04530, Mexico
4
Servicio Clínico de Enfermedades del Intersticio del Pulmón y Reumatología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Ciudad de México C.P. 14080, Mexico
5
Bioterio General, Facultad de Estudios Superiores Iztacala, UNAM, Estado de México C.P. 54090, Mexico
6
Patología Quirúrgica, Servicio de Anatomía Patológica, Hospital General de México, “Dr. Eduardo Liceaga”, México City C.P. 06726, Mexico
*
Author to whom correspondence should be addressed.
Diabetology 2026, 7(2), 31; https://doi.org/10.3390/diabetology7020031
Submission received: 10 December 2025 / Revised: 16 January 2026 / Accepted: 23 January 2026 / Published: 2 February 2026
(This article belongs to the Special Issue Animal Models for Diabetes Mellitus and Its Complications: Advantages and Limitations)
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Abstract

Background: This work aimed to determine whether curcumin influences the development of type 1 diabetes mellitus (DM) in a murine model. Methodology: Four groups of six non-obese diabetic (NOD) mice (A, B, C, and D) and one CD1 control group (E) were included. Groups A, B, and C received different doses of turmeric curcumin (50 mg/kg body weight (bw), 100 mg/kg bw, and 200 mg/kg bw, respectively) for six weeks, while groups D and E received only the vehicle simultaneously. Glycemia, body weight, and inflammatory infiltrate in the pancreatic islets were determined in all cases. Also, insulin and vitamin D receptor (VDR) expression in pancreatic cells was evaluated relative to the basal expression in the control (group E). Results: Glycemia in all the animals treated with curcumin remained stable from weeks 1 to 6, while the control group showed hyperglycemia (≥500 mg/dL) and weight loss (16.7 g ± 1 g). Treated animals had less inflammatory infiltrate, while maintaining insulin and VDR expression in the pancreas, compared with the control group. Finally, the serum concentrations of proinflammatory cytokines in treated animals were statistically lower than in the control group without curcumin. Conclusions: Curcumin delays the onset of T1DM and reduces pancreatic inflammatory infiltrate.
Keywords: type 1 diabetes mellitus; curcumin; anti-inflammatory effect type 1 diabetes mellitus; curcumin; anti-inflammatory effect
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MDPI and ACS Style

Ramos-Martínez, E.; Falfán-Valencia, R.; Pérez-Rubio, G.; García-Vázquez, F.J.; Rojas-Serrano, J.; Heredia-Antúnez, A.P.; Aristi-Urista, G.; Chavarria-Krauser, A. Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice. Diabetology 2026, 7, 31. https://doi.org/10.3390/diabetology7020031

AMA Style

Ramos-Martínez E, Falfán-Valencia R, Pérez-Rubio G, García-Vázquez FJ, Rojas-Serrano J, Heredia-Antúnez AP, Aristi-Urista G, Chavarria-Krauser A. Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice. Diabetology. 2026; 7(2):31. https://doi.org/10.3390/diabetology7020031

Chicago/Turabian Style

Ramos-Martínez, Espiridión, Ramcés Falfán-Valencia, Gloria Pérez-Rubio, Francisco Javier García-Vázquez, Jorge Rojas-Serrano, Anayántzin Paulina Heredia-Antúnez, Gerardo Aristi-Urista, and Anahí Chavarria-Krauser. 2026. "Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice" Diabetology 7, no. 2: 31. https://doi.org/10.3390/diabetology7020031

APA Style

Ramos-Martínez, E., Falfán-Valencia, R., Pérez-Rubio, G., García-Vázquez, F. J., Rojas-Serrano, J., Heredia-Antúnez, A. P., Aristi-Urista, G., & Chavarria-Krauser, A. (2026). Treatment with Curcumin Delays the Development of Type 1 Diabetes Mellitus by Decreasing Proinflammatory Cytokines in Non-Obese Diabetic Mice. Diabetology, 7(2), 31. https://doi.org/10.3390/diabetology7020031

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