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Review

Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella

1
Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
2
Vaccine and Infectious Disease Organization, Saskatoon, SK S7N 5E3, Canada
3
David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Cédric Delattre, Paolina Lukova and Guillaume Pierre
Polysaccharides 2021, 2(3), 691-714; https://doi.org/10.3390/polysaccharides2030042
Received: 14 July 2021 / Revised: 16 August 2021 / Accepted: 26 August 2021 / Published: 11 September 2021
(This article belongs to the Collection Current Opinion in Polysaccharides)
Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented to the human immune system. As a result, many vaccines have been or currently are being developed against carbohydrate antigens. In this review, we explore the diversity of capsular polysaccharides (CPS) in Salmonella and other selected bacterial species and explain the classification and function of CPS as vaccine antigens. Despite many vaccines being developed using carbohydrate antigens, the low immunogenicity and the diversity of infecting strains and serovars present an antigen formulation challenge to manufacturers. Vaccines tend to focus on common serovars or have changing formulations over time, reflecting the trends in human infection, which can be costly and time-consuming. We summarize the approaches to generate carbohydrate-based vaccines for Salmonella, describe vaccines that are in development and emphasize the need for an effective vaccine against non-typhoidal Salmonella strains. View Full-Text
Keywords: carbohydrate; bacterial vaccines; Salmonella; typhoid fever; gastroenteritis; T-cell-independent antigen; capsule; capsular polysaccharide carbohydrate; bacterial vaccines; Salmonella; typhoid fever; gastroenteritis; T-cell-independent antigen; capsule; capsular polysaccharide
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MDPI and ACS Style

Perera, S.R.; Sokaribo, A.S.; White, A.P. Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella. Polysaccharides 2021, 2, 691-714. https://doi.org/10.3390/polysaccharides2030042

AMA Style

Perera SR, Sokaribo AS, White AP. Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella. Polysaccharides. 2021; 2(3):691-714. https://doi.org/10.3390/polysaccharides2030042

Chicago/Turabian Style

Perera, Sumudu R., Akosiererem S. Sokaribo, and Aaron P. White 2021. "Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella" Polysaccharides 2, no. 3: 691-714. https://doi.org/10.3390/polysaccharides2030042

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