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Systematic Review

The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis

by
Dmitrii N. Andreev
1,*,
Alsu R. Khurmatullina
1,*,
Igor V. Maev
1,
Dmitry S. Bordin
1,2,3,
Sayar R. Abdulkhakov
4,5,
Yury A. Kucheryavyy
6,
Petr A. Beliy
1 and
Filipp S. Sokolov
7
1
Department of Internal Disease Propaedeutics and Gastroenterology, Russian University of Medicine, 127473 Moscow, Russia
2
Department of Pancreatic, Biliary and Upper Digestive Tract Disorders, A. S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia
3
Department of General Medical Practice and Family Medicine, Tver State Medical University, 170100 Tver, Russia
4
Department of Internal Diseases, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, Russia
5
Department of Primary Care and General Practice, Kazan State Medical University, 420012 Kazan, Russia
6
Ilyinskaya Hospital, 143421 Krasnogorsk, Russia
7
Department of Pharmacology, Russian University of Medicine, 127473 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Epidemiologia 2025, 6(3), 47; https://doi.org/10.3390/epidemiologia6030047
Submission received: 30 March 2025 / Revised: 28 July 2025 / Accepted: 7 August 2025 / Published: 12 August 2025
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Abstract

Objective: The objective of this study is to assess the dynamics of Helicobacter pylori infection prevalence among adults in Russia. Methods: A systematic search was conducted in MEDLINE/PubMed, EMBASE, Cochrane, RSCI, and Google Scholar for studies published between 1985 and 27 February 2025, following PRISMA guidelines. The meta-analysis was registered in PROSPERO (CRD420251011643). Results: Twenty studies were included (n = 117,841; weighted mean age: 43.71 ± 16.23 years), all using validated diagnostic methods. The pooled prevalence from 1994 to 2024 was 62.847% (95% CI: 55.101–70.274), including 45.143% (95% CI: 41.390–48.923) by the 13C-urea breath test and 75.806% (95% CI: 64.213–85.742) by serology. Prevalence declined over time: it was 79.334% before 2005, 74.074% in 2006–2011, and 66.319% in 2012–2017, and it has been 42.949% since 2018. Meta-regression confirmed a significant decrease (coefficient: −3.773% per year, p < 0.001). Conclusions: A significant decline in the prevalence of H. pylori has been observed, however, it remains relatively high and requires continued efforts aimed at diagnosis and eradication.
Keywords: H. pylori; epidemiology; prevalence; Russia; dynamics; eradication H. pylori; epidemiology; prevalence; Russia; dynamics; eradication

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MDPI and ACS Style

Andreev, D.N.; Khurmatullina, A.R.; Maev, I.V.; Bordin, D.S.; Abdulkhakov, S.R.; Kucheryavyy, Y.A.; Beliy, P.A.; Sokolov, F.S. The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia 2025, 6, 47. https://doi.org/10.3390/epidemiologia6030047

AMA Style

Andreev DN, Khurmatullina AR, Maev IV, Bordin DS, Abdulkhakov SR, Kucheryavyy YA, Beliy PA, Sokolov FS. The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia. 2025; 6(3):47. https://doi.org/10.3390/epidemiologia6030047

Chicago/Turabian Style

Andreev, Dmitrii N., Alsu R. Khurmatullina, Igor V. Maev, Dmitry S. Bordin, Sayar R. Abdulkhakov, Yury A. Kucheryavyy, Petr A. Beliy, and Filipp S. Sokolov. 2025. "The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis" Epidemiologia 6, no. 3: 47. https://doi.org/10.3390/epidemiologia6030047

APA Style

Andreev, D. N., Khurmatullina, A. R., Maev, I. V., Bordin, D. S., Abdulkhakov, S. R., Kucheryavyy, Y. A., Beliy, P. A., & Sokolov, F. S. (2025). The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia, 6(3), 47. https://doi.org/10.3390/epidemiologia6030047

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