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Endocrines, Volume 1, Issue 2

December 2020 - 6 articles

Cover Story: MEN1 mutation predisposes patients to multiple endocrine neoplasia type 1 (MEN1), a genetic syndrome associated with the predominant co-occurrence of endocrine tumors. Intriguingly, recent evidence has suggested that MEN1 could also be involved in the development of breast and prostate cancers, two major hormone-related cancers. In this review, we present the currently available data obtained from mouse models and patients, and molecular studies carried out in endocrine and hormone-related cell lines, including, in particular, the physical and functional interactions between the menin protein, encoded by the MEN1 gene, and estrogen receptor α and androgen receptor. The data highlight a complex and multifaceted role of MEN1 in these two types of hormone-dependent cancers. View this paper

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Articles (6)

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Review

9 Citations

11,325 Views

13 Pages

Steroid-Induced Iatrogenic Adrenal Insufficiency in Children: A Literature Review

Shogo Akahoshi and
Yukihiro Hasegawa

Endocrines2020, 1(2), 125-137;https://doi.org/10.3390/endocrines1020012

9 December 2020

The present review focuses on steroid-induced adrenal insufficiency (SIAI) in children and discusses the latest findings by surveying recent studies. SIAI is a condition involving adrenocorticotropic hormone (ACTH) and cortisol suppression due to hig...

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Communication

10 Citations

4,918 Views

6 Pages

Testosterone Responses to Intensive, Prolonged Endurance Exercise in Women

Anthony C. Hackney and
Hannah N. Willett

Endocrines2020, 1(2), 119-124;https://doi.org/10.3390/endocrines1020011

5 November 2020

Objective: To examine the response of testosterone in women to an intensive, prolonged endurance exercise bout that mimicked a competitive event. Methods: Ten healthy eumenorrheic women ran to exhaustion at ~100% of their ventilatory threshold in the...

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Feature Paper
Article

12 Citations

6,056 Views

17 Pages

Malignancy Analyses of Thyroid Nodules in Patients Subjected to Surgery with Cytological- and Ultrasound-Based Risk Stratification Systems

Stefania Giuliano,
Maria Mirabelli,
Eusebio Chiefari,
Margherita Vergine,
Rita Gervasi,
Francesco S. Brunetti,
Nadia Innaro,
Giuseppe Donato,
Antonio Aversa and
Antonio Brunetti

Endocrines2020, 1(2), 102-118;https://doi.org/10.3390/endocrines1020010

3 November 2020

The fine needle aspiration (FNA) cytology is the gold standard for the preoperative diagnosis of thyroid cancer. However, up to 30% of FNA examinations yield nondiagnostic or indeterminate results and this complicates patient management. Clinical fea...

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Communication

8 Citations

8,367 Views

12 Pages

PDE5 Inhibitors in Type 2 Diabetes Cardiovascular Complications

Federica Barbagallo,
Federica Campolo,
Edoardo Franceschini,
Elena Crecca,
Riccardo Pofi,
Andrea M. Isidori and
Mary Anna Venneri

Endocrines2020, 1(2), 90-101;https://doi.org/10.3390/endocrines1020009

29 October 2020

Pharmacological inhibition of Phosphodiesterase type 5 (PDE5) proved its efficacy treating several pathological conditions, such as erectile dysfunction and pulmonary hypertension. Nowadays, its benefits on cardiovascular diseases are well documented...

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Brief Report

2,988 Views

8 Pages

History of Radiation to the Neck Increases the Risk of Denovo Thyroid Dysfunction after Receiving Immune Checkpoint Inhibitors

Koosha Paydary,
Muhammad Zain Farooq and
Ankit Mangla

Endocrines2020, 1(2), 82-89;https://doi.org/10.3390/endocrines1020008

26 October 2020

Thyroid dysfunction is a common endocrine side effect of immune checkpoint inhibitors (ICI). We designed a retrospective study, including patients who received ICI for any cancer at our institution. Thyroid-stimulating hormone (TSH), free T4 levels,...

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Feature Paper
Review

3 Citations

7,784 Views

24 Pages

Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations

Razan Abou Ziki,
Yakun Luo,
Virginie Vlaeminck-Guillem,
Muriel Le Romancer and
Chang Xian Zhang

Endocrines2020, 1(2), 58-81;https://doi.org/10.3390/endocrines1020007

1 October 2020

MEN1 mutation predisposes patients to multiple endocrine neoplasia type 1 (MEN1), a genetic syndrome associated with the predominant co-occurrence of endocrine tumors. Intriguingly, recent evidence has suggested that MEN1 could also be involved in th...

Full Article

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