Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract
Abstract
:1. Introduction
2. Results and Discussions
2.1. Isolated Compounds from the DCM Crude Extract of T. diversifolia Leaves
2.2. The Flavonol
3. Materials and Methods
3.1. Characterisation of Isolates
3.2. Crude Extracts
3.3. Antiplasmodial Activity Assessment
3.4. Isolation of Antiplasmodial Active Fractions
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Position | 1H NMR/ δ (ppm) (600 MHz, DMSO-d6) | 13C NMR/ δ (ppm) (150 MHz, DMSO-d6) | |
---|---|---|---|
1 | - | - | - |
2 | - | - | 164.2 |
3 | - | - | 153.2 |
4 | - | - | 182.5 |
4a | - | - | 157.8 |
5 | H-5 | 6.77 (1H, s) | 94.7 |
6 | - | - | 104.5 |
7 | - | - | 131.8 |
8 | H-8 | 6.59 (1H, s) | 102.8 |
8a | - | - | 152.8 |
1′ | - | - | 161.6 |
2′ | H-2′ | 7.92 (1H, d, J = 8.8 Hz) | 128.9 |
3′ | H-3′ | 6.92 (1H, d, J = 8.8 Hz) | 116.4 |
4′ | - | - | 121.6 |
5′ | H-5′ | 6.92 (1H, d, J = 8.8 Hz) | 116.4 |
6′ | H-6′ | 7.92 (1H, d, J = 8.8 Hz) | 128.9 |
-OMe | 3.75 (3H, s) | 60.4 | |
-OH | 13.07 (1H, s) | - |
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Ngarivhume, T.; Noreljaleel, A.; Bonnet, S.L.; Wilhelm, A. Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract. Chemistry 2021, 3, 854-860. https://doi.org/10.3390/chemistry3030062
Ngarivhume T, Noreljaleel A, Bonnet SL, Wilhelm A. Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract. Chemistry. 2021; 3(3):854-860. https://doi.org/10.3390/chemistry3030062
Chicago/Turabian StyleNgarivhume, Talkmore, Anwar Noreljaleel, Susanna L. Bonnet, and Anke Wilhelm. 2021. "Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract" Chemistry 3, no. 3: 854-860. https://doi.org/10.3390/chemistry3030062