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Clocks & Sleep
Volume 5
Issue 2
10.3390/clockssleep5020025
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Review

The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

by
Victoria Sircu
1,
Silvia-Iaroslava Colesnic
1,
Serghei Covantsev
2,3,
Olga Corlateanu
4,
Anna Sukhotko
5,
Cristian Popovici
1 and
Alexandru Corlateanu
1,*
1
Division of Pneumology and Allergology, Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, Moldova
2
Department of Clinical Research and Development, Botkin Hospital, 125284 Moscow, Russia
3
Department of Emergency Medicine № 76, Botkin Hospital, 125284 Moscow, Russia
4
Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, Moldova
5
Department of General Oncology № 71, Botkin Hospital, 125284 Moscow, Russia
*
Author to whom correspondence should be addressed.
Clocks & Sleep 2023, 5(2), 333-349; https://doi.org/10.3390/clockssleep5020025
Submission received: 2 April 2023 / Revised: 22 May 2023 / Accepted: 13 June 2023 / Published: 19 June 2023
(This article belongs to the Section Disorders)
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Abstract

Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.
Keywords: OSAS; CPAP; diabetes mellitus; hypertension; ischemic heart disease; stroke; renal failure OSAS; CPAP; diabetes mellitus; hypertension; ischemic heart disease; stroke; renal failure

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MDPI and ACS Style

Sircu, V.; Colesnic, S.-I.; Covantsev, S.; Corlateanu, O.; Sukhotko, A.; Popovici, C.; Corlateanu, A. The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & Sleep 2023, 5, 333-349. https://doi.org/10.3390/clockssleep5020025

AMA Style

Sircu V, Colesnic S-I, Covantsev S, Corlateanu O, Sukhotko A, Popovici C, Corlateanu A. The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & Sleep. 2023; 5(2):333-349. https://doi.org/10.3390/clockssleep5020025

Chicago/Turabian Style

Sircu, Victoria, Silvia-Iaroslava Colesnic, Serghei Covantsev, Olga Corlateanu, Anna Sukhotko, Cristian Popovici, and Alexandru Corlateanu. 2023. "The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP" Clocks & Sleep 5, no. 2: 333-349. https://doi.org/10.3390/clockssleep5020025

APA Style

Sircu, V., Colesnic, S.-I., Covantsev, S., Corlateanu, O., Sukhotko, A., Popovici, C., & Corlateanu, A. (2023). The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP. Clocks & Sleep, 5(2), 333-349. https://doi.org/10.3390/clockssleep5020025

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