Solvent Accessibility of Coronaviridae Spike Proteins through the Lens of Information Gain

Round 1

Reviewer 1 Report

Please see the attached document for the review report.

Comments for author File: Comments.pdf

Author Response

Please see our response in the attached pdf

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments for author File: Comments.docx

Author Response

Please see our response in the attached pdf

Author Response File: Author Response.pdf

Reviewer 3 Report

·         In line 122: what “Combining” means, there is no numbering, and the word followed by full stop.

·         In line 127, it is not scientifically to mention “we” in the text: “We then considered only the “major” subgenera and hosts”. Please state the sentence in passive.

·         The titles of tables 2 and 3 are not sufficient

·         Please mention the reference of the data in tables 2 and 3.

·         Also, the titles of Tables 4 and 5 are not sufficient

·         In figure 2, please provide more information about the data obtained in this figure, illustrate more about genera and subgenus.

·         In figure 3, state that “as mentioned in table 2”, not “Table 2” only.

·         In all tables, all the titles should be above the tables not beneath.

·         In figure 4, is it correct to say “The Figure is best seen in color” in the figure title?

·         The number of references is too little, only 16.

·         What is the importance of section 4 “case study”?

Author Response

Please see our response in the attached pdf

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

please find the recommendations in the attachment.

Comments for author File: Comments.pdf

Reviewer 3 Report

thanks a lot for clarifying the points mentioned in the revision