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Review

Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2

Department of Biotechnology and Consumer Sciences, Faculty of Applied Sciences, Cape Peninsula University of Technology, District Six Campus, Cape Town 7530, South Africa
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Academic Editor: Jon Øyvind Odland
J 2021, 4(4), 824-837; https://doi.org/10.3390/j4040056
Received: 15 September 2021 / Revised: 12 October 2021 / Accepted: 13 October 2021 / Published: 29 November 2021
(This article belongs to the Section Medicine & Pharmacology)
Modified pectin (MP) is a bioactive complex polysaccharide that is broken down into smaller fragments of units and used as an oral dietary supplement for cell proliferation. MP is safe and non-toxic with promising therapeutic properties with regard to targeting galectin-3 (GAL-3) toward the prevention and inhibition of viral infections through the modulation of the immune response and anti-inflammatory cytokine effects. This effect of MP as a GAL-3 antagonism, which has shown benefits in preclinical and clinical models, may be of relevance to the progression of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in coronavirus disease 2019 patients. The outbreak of emerging infectious diseases continues to pose a threat to human health. Further to the circulation of multiple variants of SARS-CoV-2, an effective and alternative therapeutic approach to combat it has become pertinent. The use of MP as a GAL-3 inhibitor could serve as an antiviral agent blocking against the SARS-CoV-2-binding spike protein. This review highlights the potential effects of MP in viral infections, its proposed role as a GAL-3 inhibitor, and the associated function concerning a SARS-CoV-2 infection. View Full-Text
Keywords: modified pectin; galectin-3; SARS-CoV-2; polysaccharide; COVID-19; inflammation; immune response modified pectin; galectin-3; SARS-CoV-2; polysaccharide; COVID-19; inflammation; immune response
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MDPI and ACS Style

Odun-Ayo, F.; Reddy, L. Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2. J 2021, 4, 824-837. https://doi.org/10.3390/j4040056

AMA Style

Odun-Ayo F, Reddy L. Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2. J. 2021; 4(4):824-837. https://doi.org/10.3390/j4040056

Chicago/Turabian Style

Odun-Ayo, Frederick, and Lalini Reddy. 2021. "Potential Roles of Modified Pectin Targeting Galectin-3 against Severe Acute Respiratory Syndrome Coronavirus-2" J 4, no. 4: 824-837. https://doi.org/10.3390/j4040056

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