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Reports, Volume 4, Issue 1

March 2021 - 8 articles

Cover Story: The immune system has complementary functions, defending the organism from bacteria, viruses, or tumor cells (immune response), but also following a narrow line, it identifies and respects its own structures. For this immunological tolerance, there are key points such as CTLA-4 or PD-1 that modulate the activation of the immune system. Blocking these pathways with Tremelimumab (anti-CTLA-4 antibody) or Durvalumab (anti-PD-L1 antibody), immune response against cancer is boosted, but autoimmune diseases are frequently triggered by breaking previous immune tolerance as adverse events. View this paper
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Articles (8)

  • Review
  • Open Access
19,411 Views
16 Pages

23 March 2021

In this review we discuss the significance of the main ultrasonographic features of common thyroid and parathyroid conditions, with a focus on the advantages of real time observation. The thyroid specialist, defined as an endocrinologist with a major...

  • Article
  • Open Access
5 Citations
3,609 Views
11 Pages

Metagenome Techniques for Detection of Pathogens Causing Ocular Infection

  • Tatsuhiko Kobayashi,
  • Takashi Suzuki,
  • Yukinobu Okajima,
  • Kotaro Aoki,
  • Yoshikazu Ishii,
  • Kazuhiro Tateda and
  • Yuichi Hori

Metagenomic analysis is the comprehensive study of DNA using clinical specimens of organisms including bacteria, fungi, and viruses. In this study, we investigated the efficacy of metagenomic analysis for diagnosing ocular infections, including 11 ke...

  • Brief Report
  • Open Access
1 Citations
3,042 Views
11 Pages

AHR:IKAROS Interaction Promotes Platelet Biogenesis in Response to SR1

  • Lea Mallo,
  • Valentin Do Sacramento,
  • Christian Gachet,
  • Susan Chan,
  • Philippe Kastner,
  • François Lanza,
  • Henri de la Salle and
  • Catherine Strassel

In vitro, the differentiation of megakaryocytes (MKs) is improved by aryl-hydrocarbon receptor (AHR) antagonists such as StemRegenin 1 (SR1), an effect physiologically recapitulated by the presence of stromal mesenchymal cells (MSC). This inhibition...

  • Case Report
  • Open Access
2 Citations
3,794 Views
7 Pages

A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue

  • Sawako Ono,
  • Takuma Makino,
  • Hiroyuki Yanai,
  • Hotaka Kawai,
  • Kiyofumi Takabatake,
  • Keisuke Nakano,
  • Kenji Nishida,
  • Kohei Taniguchi,
  • Tomohiro Toji and
  • Hitoshi Nagatsuka
  • + 1 author

22 February 2021

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old m...

  • Case Report
  • Open Access
2 Citations
5,222 Views
9 Pages

A Case Report of Primordial Odontogenic Tumor That Required Distinction from a Dentigerous Cyst

  • Sawako Ono,
  • Hotaka Kawai,
  • Shintaro Sukegawa,
  • Kiyofumi Takabatake,
  • Keisuke Nakano,
  • Hitoshi Nagatsuka and
  • Tadashi Yoshino

9 February 2021

Primordial odontogenic tumor (POT) is a rare odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla and covered by cuboidal to columnar epithelium. We herein report a case of POT in a 14-y...

  • Case Report
  • Open Access
1 Citations
3,927 Views
5 Pages

25 January 2021

Anatomical variation is defined as the normal range of possibilities in the topography and morphology of body structures. In contrast, an anomaly is any structural or functional anatomical finding beyond the normal range of possibilities. This case s...

  • Case Report
  • Open Access
2 Citations
2,894 Views
6 Pages

Polyglandular Autoimmune Syndrome Triggered after CTLA-4 and PD-1L Immunotherapy Treatment

  • Juan Luis Fernández-Morera,
  • Alfredo Renilla González,
  • Carmen Elena Calvo Rodríguez and
  • Judit Romano-García

14 January 2021

Background: CTLA-4 and PD-1L are novel immune checkpoint targets for cancer treatment with specific side effects such as autoimmune diseases. Less frequently, the presence of several autoimmune diseases in the same patient has been described. In this...

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Reports - ISSN 2571-841X