Next Article in Journal / Special Issue
Thermal Transformation of Caffeic Acid on the Nanoceria Surface Studied by Temperature Programmed Desorption Mass-Spectrometry, Thermogravimetric Analysis and FT–IR Spectroscopy
Previous Article in Journal
Comparative Study of Printed Multilayer OLED Fabrication through Slot Die Coating, Gravure and Inkjet Printing, and Their Combination
Previous Article in Special Issue
Removal of Rhodamine B (A Basic Dye) and Acid Yellow 17 (An Acidic Dye) from Aqueous Solutions by Ordered Mesoporous Carbon and Commercial Activated Carbon
Article Menu

Export Article

Open AccessArticle

Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide

School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
Surface Analysis Laboratory, School of Environment and Technology, University of Brighton, Brighton BN2 4GJ, UK
ANAMAD Ltd., Science Innovation Park, Science Park Square, Falmer, Brighton BN1 9SB, UK
Author to whom correspondence should be addressed.
Colloids Interfaces 2019, 3(1), 33;
Received: 22 December 2018 / Revised: 16 February 2019 / Accepted: 4 March 2019 / Published: 9 March 2019
PDF [2509 KB, uploaded 9 March 2019]


Nitric oxide (NO) generating surfaces are potentially promising for improving haemocompatibility of blood-contacting biomaterials. In the present report, Cu-modified poly(vinyl chloride) (PVC) and polyurethane (PU) were prepared via polydopamine (pDA)-assisted chelation. The copper content on the PVC and PU modified surfaces, assessed by inductively coupled plasma - optical emission spectrometry (ICP-OES), were about 3.86 and 6.04 nmol·cm−2, respectively. The Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) data suggest that copper is attached to the polymer surface through complex formation with pDA. The cumulative leaching of copper from modified PVC and PU during the five day incubation in phosphate buffered saline (PBS), measured by inductively coupled plasma mass spectrometry (ICP-MS), was about 50.7 ppb and 48 ppb, respectively which is within its physiological level. Modified polymers were tested for their ability to catalytically generate NO by decomposing of endogenous S-nitrosothiol (GSNO). The obtained data show that Cu-modified PVC and PU exhibited the capacity to generate physiological levels of NO which could be a foundation for developing new biocompatible materials with NO-based therapeutics. View Full-Text
Keywords: nitric oxide; S-nitrosothiol (GSNO); copper; polydopamine; poly(vinyl chloride) (PVC); polyurethane (PU) nitric oxide; S-nitrosothiol (GSNO); copper; polydopamine; poly(vinyl chloride) (PVC); polyurethane (PU)

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Azizova, L.; Ray, S.; Mikhalovsky, S.; Mikhalovska, L. Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide. Colloids Interfaces 2019, 3, 33.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Colloids Interfaces EISSN 2504-5377 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top