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Open AccessArticle

Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide

1
School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, UK
2
Surface Analysis Laboratory, School of Environment and Technology, University of Brighton, Brighton BN2 4GJ, UK
3
ANAMAD Ltd., Science Innovation Park, Science Park Square, Falmer, Brighton BN1 9SB, UK
*
Author to whom correspondence should be addressed.
Colloids Interfaces 2019, 3(1), 33; https://doi.org/10.3390/colloids3010033
Received: 22 December 2018 / Revised: 16 February 2019 / Accepted: 4 March 2019 / Published: 9 March 2019
Nitric oxide (NO) generating surfaces are potentially promising for improving haemocompatibility of blood-contacting biomaterials. In the present report, Cu-modified poly(vinyl chloride) (PVC) and polyurethane (PU) were prepared via polydopamine (pDA)-assisted chelation. The copper content on the PVC and PU modified surfaces, assessed by inductively coupled plasma - optical emission spectrometry (ICP-OES), were about 3.86 and 6.04 nmol·cm−2, respectively. The Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) data suggest that copper is attached to the polymer surface through complex formation with pDA. The cumulative leaching of copper from modified PVC and PU during the five day incubation in phosphate buffered saline (PBS), measured by inductively coupled plasma mass spectrometry (ICP-MS), was about 50.7 ppb and 48 ppb, respectively which is within its physiological level. Modified polymers were tested for their ability to catalytically generate NO by decomposing of endogenous S-nitrosothiol (GSNO). The obtained data show that Cu-modified PVC and PU exhibited the capacity to generate physiological levels of NO which could be a foundation for developing new biocompatible materials with NO-based therapeutics. View Full-Text
Keywords: nitric oxide; S-nitrosothiol (GSNO); copper; polydopamine; poly(vinyl chloride) (PVC); polyurethane (PU) nitric oxide; S-nitrosothiol (GSNO); copper; polydopamine; poly(vinyl chloride) (PVC); polyurethane (PU)
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Azizova, L.; Ray, S.; Mikhalovsky, S.; Mikhalovska, L. Development of Cu-Modified PVC and PU for Catalytic Generation of Nitric Oxide. Colloids Interfaces 2019, 3, 33.

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