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Open AccessExtended Abstract

Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs

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Novosibirsk Institute of Organic Chemistry, Novosibirsk 630090, Russia
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Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
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School of Chemical Sciences, University of Auckland, Auckland 1142, New Zealand
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Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 35; https://doi.org/10.3390/proceedings2019022035
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
Note: In lieu of an abstract, this is an excerpt from the first page.

The cytotoxic effects of chemotherapy and radiation that are clinically used to treat malignancies are directly related to their propensity to generate DNA damage. [...]
Keywords: anticancer agent; Tdp1 inhibitor; DNA repair enzyme; synthesis; usnic acid; pentathiepine; adamantane; molecular modeling; terpene; coumarin anticancer agent; Tdp1 inhibitor; DNA repair enzyme; synthesis; usnic acid; pentathiepine; adamantane; molecular modeling; terpene; coumarin
MDPI and ACS Style

Volcho, K.; Zakharenko, A.; Luzina, O.; Khomenko, T.; Suslov, E.; Salomatina, O.; Zakharova, O.; Li-Zhulanov, N.; Reynisson, J.; Lavrik, O.; Salakhutdinov, N. Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs. Proceedings 2019, 22, 35.

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