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Extended Abstract

Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly †

by
Paola Aranda-Vargas
1,
Orlando Chávez-Moreno
1,
Sandra Rodríguez
1,
Manuel Trejo-Mandujano
1,
Paola Martínez Patiño
1,
Lena Ruiz-Azuara
2 and
Carmen Mejía
1,*
1
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Campus Juriquilla C.P. 76230, Querétaro, Mexico
2
Facultad de Química, Universidad Nacional Autónoma de México, C.U., Ciudad de México C.P. 04510, Mexico
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 34; https://doi.org/10.3390/proceedings2019022034
Published: 7 August 2019

1. Introduction

Squamous cell carcinoma (SCC) is a malignancy that has no treatment. It develops in the scaly layer of the skin and affects the thoracic, phalangeal, and scrotal limbs, among others (Vet Pathol 2013, 50 (6): 1078). Macroscopically, it presents papillae that can ulcerate and bleed. At histological level, it shows hyperkeratosis, parakeratosis, keratin beads, and cellular pleomorphism (Ginn, 2007, pp. 748–751). On the other hand, Casiopeínas® (Cas) (Ruiz-Azuara, 1992, 1996, 2002, patent US.) have shown antineoplastic activity through mitochondrial apoptosis (Biometals 2017, (1): 43). Casiopeínas represent an important therapeutic alternative for the treatment of SCC.

2. Objective

To evaluate the tumor regression of a canine squamous cell carcinoma by the treatment with Casiopeína IIgly.

3. Materials and Methods

After diagnosis of SCC, peripheral blood and urine were collected to perform blood count, urea, creatinine, phosphorus, ALT, AST, and glucose, before and after treatment. The treatment consisted of the administration of 35 mg/m2 of CasIIgly i.v. for 60 min, in 5% glucose solution. For cytology, two swabs of the lesion were taken every two hours for 6 h. The second and third doses of CasIIgly were administered every 4 h, and two swabs were taken just before the application of the drug. In conjunction with the treatment, a solution of 33.35 mg of CasIIgly dissolved in 33.5 mL of 5% glucose solution was applied directly to the neoplasm, every 12 h for 27 days.

4. Results

We did not find changes in blood or urine, so CasIIgly did not produce systemic alterations. On the other hand, the neoplastic mass decreased its size, both in diameter and in depth, all suggestive of tumor regression.

5. Conclusions

The application of CasIIgly following the treatment scheme proposed in this work is effective against CCE in dogs. However, molecular evaluations should still be done to check tumor regression.

Share and Cite

MDPI and ACS Style

Aranda-Vargas, P.; Chávez-Moreno, O.; Rodríguez, S.; Trejo-Mandujano, M.; Patiño, P.M.; Ruiz-Azuara, L.; Mejía, C. Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly. Proceedings 2019, 22, 34. https://doi.org/10.3390/proceedings2019022034

AMA Style

Aranda-Vargas P, Chávez-Moreno O, Rodríguez S, Trejo-Mandujano M, Patiño PM, Ruiz-Azuara L, Mejía C. Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly. Proceedings. 2019; 22(1):34. https://doi.org/10.3390/proceedings2019022034

Chicago/Turabian Style

Aranda-Vargas, Paola, Orlando Chávez-Moreno, Sandra Rodríguez, Manuel Trejo-Mandujano, Paola Martínez Patiño, Lena Ruiz-Azuara, and Carmen Mejía. 2019. "Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly" Proceedings 22, no. 1: 34. https://doi.org/10.3390/proceedings2019022034

APA Style

Aranda-Vargas, P., Chávez-Moreno, O., Rodríguez, S., Trejo-Mandujano, M., Patiño, P. M., Ruiz-Azuara, L., & Mejía, C. (2019). Regression of an Epidermoid Carcinomas in Domestic Canine Treated with Casiopeína® IIgly. Proceedings, 22(1), 34. https://doi.org/10.3390/proceedings2019022034

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