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Proceedings 2019, 11(1), 14; https://doi.org/10.3390/proceedings2019011014

Nano or Micro: 3 Different Particles to Deliver and Protect S-Nitrosoglutathione for Oral Route Administration

Université de Lorraine, CITHEFOR, F-54000 Nancy, France
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Author to whom correspondence should be addressed.
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Published: 16 April 2019
PDF [192 KB, uploaded 16 April 2019]

Abstract

As a physiological nitric oxide donor, S-nitrosoglutathione (GSNO) is a promising candidate for several diseases (e.g., stroke and atherosclerosis). However, its clinical application has been limited by its low stability. In order to protect GSNO suitable for oral route administration and to achieve sustained release, 3 different particles from nano-size to micro-size were obtained by a water-in-oil-in-water (W/O/W) or solid-in-oil-in-water (S/O/W) double emulsion/solvent evaporation method. The 3 different particles tuned out to have similar encapsulation efficiency while the microparticles showed longer release time. Finally, the 3 formulations have been successfully lyophilized for long term stability.
Keywords: S-nitrosoglutathione; nitric oxide donor; oral delivery; sustained release; storage stability S-nitrosoglutathione; nitric oxide donor; oral delivery; sustained release; storage stability
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhou, Y.; Gaucher, C.; Fries, I.; Parent, M. Nano or Micro: 3 Different Particles to Deliver and Protect S-Nitrosoglutathione for Oral Route Administration. Proceedings 2019, 11, 14.

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