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Proceeding Paper

Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays †

by
Gabriel Lemercier
1,2,
Fadhila Sekli-Belaïdi
1,
Suresh Vajrala
3,
Emeline Descamps
1,
Julie Foncy
1,
Stéphane Arbault
3,
Jean-Emmanuel Sarry
2,
Pierre Temple-Boyer
1 and
Jérôme Launay
1,*
1
Laboratory for Analysis and Architecture of Systems (LAAS-CNRS), 31400 Toulouse, France
2
Cancer Research Center of Toulouse (CRCT-INSERM), Toulouse, France
3
L’Institut des Sciences Moléculaires (ISM-CNRS), Bordeaux, France
*
Author to whom correspondence should be addressed.
†
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
Proceedings 2017, 1(4), 289; https://doi.org/10.3390/proceedings1040289
Published: 25 August 2017
(This article belongs to the Proceedings of Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017)
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Abstract

This work deals with the development of electrochemical transducers for the analysis of the metabolic status of mitochondria isolated from leukemic cells. It proposes the use of ring nanoelectrodes (RNE) integrated into microwell arrays for the simultaneous monitoring of the oxygen (O2) consumption and the hydrogen peroxide (H2O2) production. The sensor enabled the real-time recording of the oxygen consumption of approximately 10,000 isolated mitochondria. Solutions are now proposed to detect H2O2 production and to reduce the number of mitochondria under test, targeting the single mitochondrion analysis.
Keywords: bioelectrochemical nanosensor; microwell arrays; isolated mitochondria; acute myeloid leukemia bioelectrochemical nanosensor; microwell arrays; isolated mitochondria; acute myeloid leukemia

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MDPI and ACS Style

Lemercier, G.; Sekli-Belaïdi, F.; Vajrala, S.; Descamps, E.; Foncy, J.; Arbault, S.; Sarry, J.-E.; Temple-Boyer, P.; Launay, J. Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays. Proceedings 2017, 1, 289. https://doi.org/10.3390/proceedings1040289

AMA Style

Lemercier G, Sekli-Belaïdi F, Vajrala S, Descamps E, Foncy J, Arbault S, Sarry J-E, Temple-Boyer P, Launay J. Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays. Proceedings. 2017; 1(4):289. https://doi.org/10.3390/proceedings1040289

Chicago/Turabian Style

Lemercier, Gabriel, Fadhila Sekli-Belaïdi, Suresh Vajrala, Emeline Descamps, Julie Foncy, Stéphane Arbault, Jean-Emmanuel Sarry, Pierre Temple-Boyer, and Jérôme Launay. 2017. "Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays" Proceedings 1, no. 4: 289. https://doi.org/10.3390/proceedings1040289

APA Style

Lemercier, G., Sekli-Belaïdi, F., Vajrala, S., Descamps, E., Foncy, J., Arbault, S., Sarry, J.-E., Temple-Boyer, P., & Launay, J. (2017). Toward the Analysis of Mitochondria Isolated from Leukemic Cells with Electrochemically Instrumented Microwell Arrays. Proceedings, 1(4), 289. https://doi.org/10.3390/proceedings1040289

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