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Article

HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy

by
Claudia Omes
1,*,
Mariangela Rienzi
2,
Roberta Rossini
1,
Manuela Piccinino
1 and
Rossella Elena Nappi
1,2
1
Center for Reproductive Medicine—Obstetrics and Gynecology Unit 2, Woman and Child Health Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
2
Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2025, 10(2), 36; https://doi.org/10.3390/tropicalmed10020036
Submission received: 30 September 2024 / Revised: 20 November 2024 / Accepted: 22 November 2024 / Published: 28 January 2025
(This article belongs to the Special Issue Molecular Epidemiology of Human Papillomavirus Infection)
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Abstract

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in all genders worldwide. Its association with male infertility is deeply investigated, although there are conflicting data on the role of the virus in the impairment of semen quality and reduced reproductive outcomes. In this study, we considered 335 semen samples of males (age: 37.63 ± 6.02 years) belonging to infertile couples who did not conceive a pregnancy after 12 months of unprotected intercourse. Residual semen samples, after routine sperm analysis, were used to amplify and type viral DNA. Positive or negative HPV semen samples were compared. In total, 42.51% (139/327) were positive for at least one HPV genotype, and in 54.68% (76/139), positivity was due to a high-risk (HR) genotype. The most prevalent was HPV-16 (16.55%) followed by HPV-52 (10.07%) and HPV-51 (7.91%). Overall, no significant differences emerged in terms of sperm concentration, sperm motility, and morphology between the two groups. However, a considerable reduction in sperm motility was found in the presence of HPV-51 or HPV-52. These data point to the importance of HPV screening in semen analysis to evaluate patients that might have a higher risk of infertility according to the type of HPV genotype.
Keywords: HPV; semen; sperm motility; male infertility; sperm quality; cancer; prevention HPV; semen; sperm motility; male infertility; sperm quality; cancer; prevention

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MDPI and ACS Style

Omes, C.; Rienzi, M.; Rossini, R.; Piccinino, M.; Nappi, R.E. HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy. Trop. Med. Infect. Dis. 2025, 10, 36. https://doi.org/10.3390/tropicalmed10020036

AMA Style

Omes C, Rienzi M, Rossini R, Piccinino M, Nappi RE. HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy. Tropical Medicine and Infectious Disease. 2025; 10(2):36. https://doi.org/10.3390/tropicalmed10020036

Chicago/Turabian Style

Omes, Claudia, Mariangela Rienzi, Roberta Rossini, Manuela Piccinino, and Rossella Elena Nappi. 2025. "HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy" Tropical Medicine and Infectious Disease 10, no. 2: 36. https://doi.org/10.3390/tropicalmed10020036

APA Style

Omes, C., Rienzi, M., Rossini, R., Piccinino, M., & Nappi, R. E. (2025). HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy. Tropical Medicine and Infectious Disease, 10(2), 36. https://doi.org/10.3390/tropicalmed10020036

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