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Article

Chemical Profile and In Vitro Evaluation of the Antibacterial Activity of Dioscorea communis Berry Juice

1
Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Zografou, 15771 Athens, Greece
2
Department of Pharmaceutical Technology, Unit of Dermatopharmacology, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Zografou, 15771 Athens, Greece
3
Department of Pharmaceutical Biology, Faculty of Pharmacy and Chemistry, University of Regensburg, D-93053 Regensburg, Germany
4
Laboratory of Microbial Biotechnology-Molecular Bacteriology-Virology, Department of Biochemistry & Biotechnology, Faculty of Health Sciences, University of Thessaly, 41500 Larissa, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Manuel Simões
Received: 9 March 2022 / Revised: 15 April 2022 / Accepted: 1 May 2022 / Published: 18 May 2022
Within the large family of Dioscoreaceae, Dioscorea communis (L.) Caddick & Wilkin (syn. Tamus communis L.) is considered among the four most widespread representatives in Europe, and it is commonly known under the name black bryony or bryonia. To date, reports have revealed several chemical components from the leaves and tubers of this plant. Nevertheless, an extensive phytochemical investigation has not been performed on its berry juice. In the present study, metabolite profiling procedures, using LC-MS, GC-MS, and NMR approaches, were applied to investigate the chemical profile of the D. communis berries. This work reveals the presence of several metabolites belonging to different phytochemical groups, such as fatty acid esters, alkylamides, phenolic derivatives, and organic acids, with lactic acid being predominant. In parallel, based on orally transmitted traditional uses, the initial extract and selected fractions were tested in vitro for their antibacterial effects and exhibited good activity against two bacterial strains related to skin infections: methicillin-resistant Staphylococcus aureus and Cutibacterium acnes. The MIC and MBC values of the extract were determined at 1.56% w/v against both bacteria. The results of this study provide important information on the chemical characterization of the D. communis berry juice, unveiling the presence of 71 metabolites, which might contribute to and further explain its specific antibacterial activity and its occasional toxicity. View Full-Text
Keywords: Dioscorea communis; Dioscoreaceae; GC-MC; LC-MS; NMR; antibacterial; Staphylococcus aureus; Cutibacterium acnes Dioscorea communis; Dioscoreaceae; GC-MC; LC-MS; NMR; antibacterial; Staphylococcus aureus; Cutibacterium acnes
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MDPI and ACS Style

Tsami, K.; Barda, C.; Ladopoulos, G.; Didaras, N.A.; Grafakou, M.-E.; Heilmann, J.; Mossialos, D.; Rallis, M.C.; Skaltsa, H. Chemical Profile and In Vitro Evaluation of the Antibacterial Activity of Dioscorea communis Berry Juice. Sci 2022, 4, 21. https://doi.org/10.3390/sci4020021

AMA Style

Tsami K, Barda C, Ladopoulos G, Didaras NA, Grafakou M-E, Heilmann J, Mossialos D, Rallis MC, Skaltsa H. Chemical Profile and In Vitro Evaluation of the Antibacterial Activity of Dioscorea communis Berry Juice. Sci. 2022; 4(2):21. https://doi.org/10.3390/sci4020021

Chicago/Turabian Style

Tsami, Konstantina, Christina Barda, George Ladopoulos, Nikos Asoutis Didaras, Maria-Eleni Grafakou, Jörg Heilmann, Dimitris Mossialos, Michail Christou Rallis, and Helen Skaltsa. 2022. "Chemical Profile and In Vitro Evaluation of the Antibacterial Activity of Dioscorea communis Berry Juice" Sci 4, no. 2: 21. https://doi.org/10.3390/sci4020021

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