Next Article in Journal
Deleterious Effect of Ultraviolet Radiation on Glossogobius giuris: A Short Experimental Study
Next Article in Special Issue
Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics
Previous Article in Journal
Sci: An Inclusive, Multidisciplinary Scientific Journal
Previous Article in Special Issue
Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O
 
 
Review

How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?

UTCBS (Chemical and Biological Technologies for Health Group), CNRS, INSERM, Faculté de Pharmacie, Université de Paris Cité, 4 Avenue de L’observatoire, F-75006 Paris, France
*
Author to whom correspondence should be addressed.
Academic Editor: Claus Jacob
Received: 29 November 2021 / Revised: 28 February 2022 / Accepted: 10 March 2022 / Published: 15 March 2022
(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
Pregnancy is a delicate state, during which timely investigation of possible physiological anomalies is essential to reduce the risk of maternal and fetal complications. Medical imaging encompasses different technologies to image the human body for the diagnosis, course of treatment management, and follow-up of diseases. Ultrasound (US) is currently the imaging system of choice for pregnant patients. However, sonographic evaluations can be non-effective or give ambiguous results. Therefore, magnetic resonance imaging (MRI), due to its excellent tissue penetration, the possibility of acquisition of three-dimensional anatomical information, and its high spatial resolution, is considered a valid diagnostical alternative. Nevertheless, currently employed contrast agents to improve the MRI image quality are harmful to the fetus. Because of their ability to cross the placenta, their use on pregnant patients is avoided. This review will firstly recapitulate the most common non-obstetrical, obstetrical, and fetal indications for magnetic resonance imaging on pregnant women. Fetal safety risks, due to the use of strong magnetic fields and exogenous contrast agents, will be presented. Then, possible advantages of nanostructured contrast agents compared to current molecular ones are explored. Nanosystems’ characteristics affecting contrast efficiency, and their potential for improving contrast-enhanced MRI’s safety in pregnant women, are discussed. Lastly, promising examples of nanoparticles as safer alternatives to current MRI contrast agents in pregnancy are discussed. View Full-Text
Keywords: MRI; magnetic resonance imaging; pregnancy; nanosystems; contrast agents; fetus safety; nanomedicine MRI; magnetic resonance imaging; pregnancy; nanosystems; contrast agents; fetus safety; nanomedicine
Show Figures

Figure 1

MDPI and ACS Style

Difonzo, M.; Fliedel, L.; Mignet, N.; Andrieux, K.; Alhareth, K. How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy? Sci 2022, 4, 11. https://doi.org/10.3390/sci4010011

AMA Style

Difonzo M, Fliedel L, Mignet N, Andrieux K, Alhareth K. How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy? Sci. 2022; 4(1):11. https://doi.org/10.3390/sci4010011

Chicago/Turabian Style

Difonzo, Marinella, Louise Fliedel, Nathalie Mignet, Karine Andrieux, and Khair Alhareth. 2022. "How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?" Sci 4, no. 1: 11. https://doi.org/10.3390/sci4010011

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop