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Article

Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O

1
Engineering Laboratory of Organometallic Molecular Materials and Environment, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Fez 30000, Morocco
2
ISIS Facility, STFC Rutherford Appleton Laboratory, Chilton, Oxfordshire OX11 0QX, UK
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Laboratoire Matériaux et Environnement, Faculté des Sciences, Université Ibn Zohr, Agadir 80000, Morocco
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Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Juraj Gregáň
Received: 14 November 2021 / Revised: 2 January 2022 / Accepted: 19 January 2022 / Published: 8 February 2022
(This article belongs to the Special Issue Feature Papers 2021 Editors Collection)
A novel hybrid cobalt phosphite, (H2DAB)[Co(H2PO3)4] 2H2O, was synthesized by using a slow evaporation method in the presence of cobalt nitrate, phosphorous acid, and 1,4-diaminobutane (DAB = 1,4-diaminobutane) as a structure-directing agent. Single-crystal X-ray diffraction analysis showed that the compound crystallizes in the triclinic system (space group P-1(n.2)) with the following unit cell parameters (Å, °) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5), and V = 447.33 (4) Å3. The crystal structure is built up from corner-sharing [CoO6] octahedra, forming chains parallel to [001], which are interconnected by H2PO3 pseudo-tetrahedral units. The diprotonated cations, residing between the parallel chains, interact with the inorganic moiety via hydrogen bonds, thus leading to the formation of the 3D crystal structure. The Fourier transform infrared spectrum showed characteristic bands corresponding to the phosphite group and the organic amine. The thermal behavior of the compound mainly consisted of the loss of its organic moiety and the water molecules. The biological tests exhibited significant activity against Candida albicans and Escherichia coli strains at different concentrations, while less inhibitory activity was pronounced against Staphylococcus epidermidis and Saccharomyces cerevisiae, and in the case of multi-cellular organisms, no activity against the nematode model Steinernema feltiae was detected. View Full-Text
Keywords: hybrid phosphite; X-ray crystal structure; FTIR; thermal behavior; biological activities; antimicrobial; micro-organisms hybrid phosphite; X-ray crystal structure; FTIR; thermal behavior; biological activities; antimicrobial; micro-organisms
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MDPI and ACS Style

Hamdi, N.; Chaouch, S.; da Silva, I.; Ezahri, M.; Lachkar, M.; Alhasan, R.; Abdin, A.Y.; Jacob, C.; Bali, B.E. Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O. Sci 2022, 4, 5. https://doi.org/10.3390/sci4010005

AMA Style

Hamdi N, Chaouch S, da Silva I, Ezahri M, Lachkar M, Alhasan R, Abdin AY, Jacob C, Bali BE. Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O. Sci. 2022; 4(1):5. https://doi.org/10.3390/sci4010005

Chicago/Turabian Style

Hamdi, Najlaa, Souad Chaouch, Ivan da Silva, Mohamed Ezahri, Mohammed Lachkar, Rama Alhasan, Ahmad Y. Abdin, Claus Jacob, and Brahim E. Bali. 2022. "Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O" Sci 4, no. 1: 5. https://doi.org/10.3390/sci4010005

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