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Studies on Application of Ion Beam Breeding to Industrial Microorganisms at TIARA

Department of Radiation-Applied Biology Research, Takasaki Advanced Radiation Research Institute, Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology (QST), 1233 Watanuki, Takasaki, Gunma 370-1292, Japan
Author to whom correspondence should be addressed.
Quantum Beam Sci. 2019, 3(2), 11;
Received: 17 April 2019 / Revised: 21 May 2019 / Accepted: 1 June 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Ion Beams in Biology and Medicine)
PDF [1546 KB, uploaded 5 June 2019]


Mutation-breeding technologies are useful tools for the development of new biological resources in plants and microorganisms. In Takasaki Ion Accelerators for Advanced Radiation Application (TIARA) at the National Institutes for Quantum and Radiological Science and Technology, Japan, ion beams were explored as novel mutagens. The mutagenic effects of various ion beams on eukaryotic and prokaryotic microorganisms were described and their application in breeding technology for industrial microorganisms were discussed. Generally, the relative biological effectiveness (RBE) depended on the liner energy transfer (LET) and the highest RBE values were obtained with 12C5+ ion beams. The highest mutation frequencies were obtained at radiation doses that gave 1%–10% of surviving fraction. By using 12C5+ ion beams in this dose range, many microorganisms have been improved successfully at TIARA. Therefore, ion-beam breeding technology for microorganisms will have applications in many industries, including stable food production, sustainable agriculture, environmental conservation, and development of energy resources in the near future. Moreover, genome analyses of the ion-beam-induced mutants are in progress to clear the differences of mutational functions induced by different LET radiations in microorganisms. Further characterizations of mutations induced by different LET radiations will facilitate more effective use of ion beams in microorganisms breeding. View Full-Text
Keywords: ion beam; microorganism; mutagenesis; mutation breeding; TIARA ion beam; microorganism; mutagenesis; mutation breeding; TIARA

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Satoh, K.; Oono, Y. Studies on Application of Ion Beam Breeding to Industrial Microorganisms at TIARA. Quantum Beam Sci. 2019, 3, 11.

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