Vision through Healthy Aging Eyes

Round 1

Reviewer 1 Report

The thought behind this paper is good. Although the style and presentation are good, the author(s) should reword sentences that have grammatical/punctuation errors. The authors have not given appropriate credit in citing the literature in a few instances. The authors should check that all citations relate to and support the claims made, as some references feel misplaced. The revised version of the manuscript should address this major concern.

 

Specific suggestions/comments raised by the reviewer:

Page 1, lines 7 - 9, abstract: The authors should reword this sentence to render it more comprehensible.

Page 1, lines 8-10, introduction: The authors should reword this sentence to render it more comprehensible.

Page 1, lines 4 - 7, introduction: The authors should check that these cited references relate to and support the claims made, as the cited references appear to be misplaced. 

Page 2, Visual Acuity, paragraph 1, lines 5 - 6: Which studies? Elaborate on these studies.

Page 2, Visual Acuity, paragraph 1: "A study suggested that a reduction at a younger age may possibly be partially a result of these interferences" Which study are you referring to? Elaborate on these interferences.

Page 2, Visual Acuity, paragraph 2, lines 5 - 7: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced. 

Page 2, Dry eye, Paragraph 2, line 4: bulbar redness or bulbar conjunctival redness?

Page 3, Dry Eyes, paragraph 3: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

Page 3, Dry Eyes, paragraph 3, lines 9 - 10: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

Page 3, Dry Eyes, paragraph 3, line 14: Elaborate on these external sources that contribute to meibomian gland dysfunction.

Page 3, Dry Eyes, paragraph 4, lines 1 - 2: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced. 

Page 4, Ocular motility, paragraph 1, lines 2 -4: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

Page 4, Visual Field, paragraph 2, lines 4 - 5: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

Page 5, Contrast sensitivity, paragraph 1: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced.

Page 5, Contrast sensitivity, paragraph 2, lines 1 -2: The authors should reword this sentence to render it more comprehensible.

Page 5, Contrast sensitivity, paragraph 2, line 9: The “cortex” refers to visual cortex, right?

Page 5, Dark adaptation, paragraph 1, lines 2 - 6: Consider revising this run-on sentence in order to render it comprehensible.

Page 5, Dark adaptation, paragraph 1, lines 7 - 8: Specify and elaborate on these additional studies and provide relevant citations for these studies.

Page 6, Mechanisms of aging and developing modes of intervention and prevention, paragraph 3, lines 1 - 4: The authors should reword this sentence to render it more comprehensible.

Page 9, Reference #56: This reference is incomplete. The authors should provide the name of the journal and other relevant details, if this is impossible, replace the reference.

Author Response

Re: Vision Through Healthy Aging Eyes

Responses to the reviewers' comments:

First, on behalf of all the authors I would like to thank the reviewers for the constructive comments on our manuscript. We have revised our manuscript and commented below to each of their suggestions.

Changes were left highlighted in yellow in the manuscript (where relevant) and a table indicating the place of each change was included (where relevant).

A complete review of grammar and punctuation was done on the entire manuscript as suggested and many sentences have been reworded and/or restructured.

All citations and sources have been rechecked and we took the opportunity to add more references from the literature.

We look forward to hearing from you.

Reviewer #1

The thought behind this paper is good. Although the style and presentation are good, the author(s) should reword sentences that have grammatical/punctuation errors. The authors have not given appropriate credit in citing the literature in a few instances. The authors should check that all citations relate to and support the claims made, as some references feel misplaced. The revised version of the manuscript should address this major concern. 

Specific suggestions/comments raised by the reviewer:

Page 1, lines 7 - 9, abstract: The authors should reword this sentence to render it more comprehensible.

We thank the reviewer for the comment. We have changed the manuscript and left it highlighted.

Changed manuscript	Location
"The most common…modified"	Page 1, Abstract, Line 6-10

Page 1, lines 8-10, introduction: The authors should reword this sentence to render it more comprehensible.

We thank the reviewer for the comment. We have changed the manuscript and left it highlighted.

Changed manuscript	Location
"The most prevalent…visual cortex"	Page 1, Introduction, Line 5-8

Page 1, lines 4 - 7, introduction: The authors should check that these cited references relate to and support the claims made, as the cited references appear to be misplaced. 

We thank the reviewer for the comment. We have re-checked the references and the correct ones are current #4-8

Page 2, Visual Acuity, paragraph 1, lines 5 - 6: Which studies? Elaborate on these studies.

We thank the reviewer for the comment. This sentence was a continuation of the previous sentence and therefore the wording was restructured. Hopefully now it is more comprehensible. Additional relevant sources have been added as well.

Changed manuscript	Location
"It is important…low contrast"	Page 2, visual acuity, Line 5-7

 Page 2, Visual Acuity, paragraph 1: "A study suggested that a reduction at a younger age may possibly be partially a result of these interferences"

Which study are you referring to?  

We thank the reviewer for the comment. The sentence has been reworded to reflect our intent and additional sources have been added.

Changed manuscript	Location
"It has been suggested…removed"	Page 2, visual acuity, Line 9-11

Page 2, Visual Acuity, paragraph 2, lines 5 - 7: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced. 

We thank the reviewer for the comment. We have reviewed and corrected all the references.

Page 2, Dry eye, Paragraph 2, line 4: bulbar redness or bulbar conjunctival redness?

We thank the reviewer for the comment. We have changed the manuscript and left it highlighted.

Changed manuscript	Location
bulbar conjunctival redness	Page 3, Paragraph 2, Line 4

Page 3, Dry Eyes, paragraph 3, lines 9 - 10: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

We thank the reviewer for the comment. We have rewritten the sentence and left it highlighted.

Changed manuscript	Location
"Elevated osmolality…males"	Page 3, Paragraph 3, Line 9-11

Page 3, Dry Eyes, paragraph 3, line 14: Elaborate on these external sources that contribute to meibomian gland dysfunction

We thank the reviewer for the comment. We have changed the manuscript and left it highlighted

Changed manuscript	Location
"external causes…rather than age"	Page 3 paragraph 3, last sentence

Page 3, Dry Eyes, paragraph 4, lines 1 - 2: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced. 

We thank the reviewer for the comment. We have reviewed and corrected all the references.

Page 4, Ocular motility, paragraph 1, lines 2 -4: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

We thank the reviewer for the comment. We have rewritten the sentence and left it highlighted.

Changed manuscript	Location
"These complex…become spindles"	Page 4, Ocular motility, Line 2-5

Page 4, Visual Field, paragraph 2, lines 4 - 5: The authors should reword this sentence to render it more comprehensible as well as address the minor punctuation errors.

We thank the reviewer for the comment. We have rewritten the sentence and left it highlighted.

Changed manuscript	Location
"After age…. were observed"	Page 5, Visual field, Paragraph 2, Line 4-5

Page 5, Contrast sensitivity, paragraph 1: The authors should check that these cited references relate to and support the claims made, as the cited references seem misplaced.

We thank the reviewer for the comment. We have re-checked the references and they are now #102-108

Page 5, Contrast sensitivity, paragraph 2, lines 1 -2: The authors should reword this sentence to render it more comprehensible.

We thank the reviewer for the comment. We have rewritten the sentence and left it highlighted.

Changed manuscript	Location
"In a well-lit…targets"	Page 5, Contrast sensitivity, Paragraph 2, lines 1 -2

Page 5, Contrast sensitivity, paragraph 2, line 9: The “cortex” refers to visual cortex, right?

We thank the reviewer for the comment. The word "visual" has been added in front of "cortex" and left highlighted at the location on page 6 line 6.

Page 5, Dark adaptation, paragraph 1, lines 2 - 6: Consider revising this run-on sentence in order to render it comprehensible.

We thank the reviewer for the comment. The sentence has been restructured, divided and left highlighted.

Changed manuscript	Location
"Changes in the …low illumination"	Page 6, Dark adaptation, Line 2-6

Page 5, Dark adaptation, paragraph 1, lines 7 - 8: Specify and elaborate on these additional studies and provide relevant citations for these studies.

We thank the reviewer for the comment. The paragraph has been reconstructed and sources have been added.

Page 6, Mechanisms of aging and developing modes of intervention and prevention, paragraph 3, lines 1 - 4: The authors should reword this sentence to render it more comprehensible.

We thank the reviewer for the comment. The sentence has been restructured and left highlighted.
The title of the chapter has been modified as well.

Changed manuscript	Location
"The utilization of…targets to treat"	Page 7, Developing modes, Paragraph 4, Line1-4

Page 9, Reference #56: This reference is incomplete. The authors should provide the name of the journal and other relevant details, if this is impossible, replace the reference.

We thank the reviewer for the comment. The source has been replaced with current source #96.

 

Submission Date

23 July 2021

Date of this review

10 Aug 2021 23:56:12

 

Reviewer 2 Report

The authors wrote an interesting article, few improvements are needed:

1) I'd add a section of corneal endothelium, with an evidence of the reduction of corneal endothelial cells

You could have a look to the following papers

DOI: 10.1097/ICO.0000000000002338

DOI: 10.1155/2021/1819454

doi: 10.1155/2021/6644114

Please have a look to the English level

Please review the final sentence of the final summary

What it is the goal of the review?

 

 

 

Author Response

Re: Vision Through Healthy Aging Eyes

Responses to the reviewers' comments:

First, on behalf of all the authors I would like to thank the reviewers for the constructive comments on our manuscript. We have revised our manuscript or commented below to each of their suggestions. Changes were left highlighted in yellow in the manuscript (where relevant) and a table indicating the place of each change was included (where relevant). A review of grammar and punctuation was done on the entire manuscript as suggested.

Reviewer 2

The authors wrote an interesting article, few improvements are needed:

I'd add a section of corneal endothelium, with evidence of the reduction of corneal endothelial cells
You could have a look to the following papers
DOI: 10.1097/ICO.0000000000002338
DOI: 10.1155/2021/1819454
DOI: 10.1155/2021/6644114

We thank the reviewer for the suggestion. We have added information on page 3, paragraph 3 in the dry eye section and left it highlighted. We included additional sources including the three suggested papers, and updated the figure to reflects the addition.

Addition in manuscript	Location
"An additional…increased glare"	Page 3 paragraph 4
Sources	Sources section # 60-68
Endothelial cells	Figure 1, Cornea section

Please have a look to the English level

We thank the reviewer for the suggestion- we have reviewed the entire manuscript and hope it is now acceptable.

Please review the final sentence of the final summary
What it is the goal of the review?

We thank the reviewer for the comment. We have elaborated both in the introduction and the summary accordingly and left it highlighted.

Addition in manuscript	Location
"Governments…so profoundly"	Page 7-8, summary, paragraph 2, Line 3-8
"The contemporary…mobility"	Page 2 Line 5-11

 

 

Submission Date

23 July 2021

Date of this review

09 Sep 2021 23:12:08

 

Round 2

Reviewer 1 Report

The authors have completed a good revision of the original manuscript.

Reviewer 2 Report

The authors improved the paper