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Article

Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study

1
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy
2
Department of Clinic and Experimental Medicine, University of Messina, 98124 Messina, Italy
*
Author to whom correspondence should be addressed.
J. Funct. Morphol. Kinesiol. 2020, 5(3), 65; https://doi.org/10.3390/jfmk5030065
Received: 3 July 2020 / Revised: 17 August 2020 / Accepted: 19 August 2020 / Published: 22 August 2020
(This article belongs to the Special Issue Role of Exercises in Musculoskeletal Disorders—3th Edition)
The orthodontic tooth movement is the last step of several biological processes that take place after the application of external forces. During this process, dental pulp tissue is subjected to structural and protein expression modifications in order to maintain their integrity and functional morphology. The purpose of the present work was to perform an in vivo study, evaluating protein expression modifications in the human dental pulp of patients that have undergone orthodontic tooth movement due to pre-calibrated light force application for 30 days. Dental pulp samples were extracted from molars and premolars of the control group and after 7 and 30 days of treatment; the samples were then processed for immunofluorescence reactions using antibodies against fibronectin, collagen I and vascular endothelial growth factor (VEGF). Our results show that, after 7 days of treatment, all tested proteins change their pattern expression and will reset after 30 days. These data demonstrate that the dental pulp does not involve any irreversible iatrogenic alterations, supporting the efficacy and safety of using pre-calibrated force application to induce orthodontic tooth movement in clinical practice. View Full-Text
Keywords: human dental pulp; orthodontic tooth movement; immunofluorescence; extracellular matrix proteins human dental pulp; orthodontic tooth movement; immunofluorescence; extracellular matrix proteins
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MDPI and ACS Style

Vermiglio, G.; Centofanti, A.; Matarese, G.; Militi, A.; Matarese, M.; Arco, A.; Nicita, F.; Cutroneo, G. Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study. J. Funct. Morphol. Kinesiol. 2020, 5, 65. https://doi.org/10.3390/jfmk5030065

AMA Style

Vermiglio G, Centofanti A, Matarese G, Militi A, Matarese M, Arco A, Nicita F, Cutroneo G. Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study. Journal of Functional Morphology and Kinesiology. 2020; 5(3):65. https://doi.org/10.3390/jfmk5030065

Chicago/Turabian Style

Vermiglio, Giovanna, Antonio Centofanti, Giovanni Matarese, Angela Militi, Marco Matarese, Alba Arco, Fabiana Nicita, and Giuseppina Cutroneo. 2020. "Human Dental Pulp Tissue during Orthodontic Tooth Movement: An Immunofluorescence Study" Journal of Functional Morphology and Kinesiology 5, no. 3: 65. https://doi.org/10.3390/jfmk5030065

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