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Instruments 2018, 2(3), 12; https://doi.org/10.3390/instruments2030012

Optimized Treatment and Recovery of Irradiated [18O]-Water in the Production of [18F]-Fluoride

Institute for Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine Westphalia, University Hospital, Ruhr University Bochum, 32545 Bad Oeynhausen, Germany
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Received: 28 May 2018 / Revised: 17 June 2018 / Accepted: 22 June 2018 / Published: 4 July 2018
(This article belongs to the Special Issue Instruments and Methods for Cyclotron Produced Radioisotopes)
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Abstract

Enriched [18O]-water is the target material for [18F]-fluoride production. Due to its high price and scarce availability, an increased interest and necessity has arisen to recycle the used water, in order to use it multiple times as a target material for [18F]-fluoride production. This paper presents an efficient treatment and reprocessing procedure giving rise to high chemical quality [18O]-water, thereby maintaining its enrichment grade. The reprocessing is subdivided into two main steps. In the first step, the [18F]-FDG (fluorodeoxyglucose) synthesis preparation was modified to preserve the enrichment grade. Anhydrous acetonitrile is used to dry tubing systems and cartridges in the synthesis module. Applying this procedure, the loss in the enrichment throughout the reprocessing is <1%. The second step involves a fractional distillation in which the major part of the [18O]-water was recycled. Impurities such as solvents, ions, and radioactive nuclides were almost completely separated. Due to the modified synthesis preparation using acetonitrile, the first distillation fraction contains a larger amount of an azeotropic [18O]-water/acetonitrile mixture. This fraction is not further distillable. Contents of the remaining [18O]-water were separated from the azeotropic mixture by using a molecular sieve desiccant. This process represents a fast, easy, and inexpensive method for reprocessing used [18O]-water into new [18O]-water quality for further application. View Full-Text
Keywords: recycling of [18O]-water; enrichment grade; fractional distillation; azeotropic mixtures; molecular sieve desiccant recycling of [18O]-water; enrichment grade; fractional distillation; azeotropic mixtures; molecular sieve desiccant
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Uhlending, A.; Henneken, H.; Hugenberg, V.; Burchert, W. Optimized Treatment and Recovery of Irradiated [18O]-Water in the Production of [18F]-Fluoride. Instruments 2018, 2, 12.

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