Next Article in Journal
We All Have a Role to Play: Redressing Inequities for Children Living with CAH and Other Chronic Health Conditions of Childhood in Resource-Poor Settings
Next Article in Special Issue
Translating Molecular Technologies into Routine Newborn Screening Practice
Previous Article in Journal
Newborn Critical Congenital Heart Disease Screening Using Pulse Oximetry: Value and Unique Challenges in Developing Regions
Previous Article in Special Issue
National Program for External Quality Assessment of Chinese Newborn Screening Laboratories
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
IJNS
Volume 6
Issue 3
10.3390/ijns6030075
IJNS-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement question_answer thumb_up
...
textsms
...
Article

Harmonizing Newborn Screening Laboratory Proficiency Test Results Using the CDC NSQAP Reference Materials

by
Charles Austin Pickens
1,
Maya Sternberg
1,
Mary Seeterlin
2,
Víctor R. De Jesús
3,
Mark Morrissey
4,
Adrienne Manning
5,
Sonal Bhakta
6,
Patrice K. Held
7,
Joanne Mei
1,
Carla Cuthbert
1 and
Konstantinos Petritis
1,*
1
Centers for Disease Control and Prevention, Division of Laboratory Sciences, Newborn Screening and Molecular Biology Branch, MS F19, Atlanta, GA 30341, USA
2
Michigan Department of Community Health, Lansing, MI 49221, USA
3
Centers for Disease Control and Prevention, Division of Laboratory Sciences, Tobacco and Volatiles Branch, Atlanta, GA 30341, USA
4
Wadsworth Center/New York State Department of Health, Albany, NY 12201-0509, USA
5
Katherine A. Kelley State Public Health Laboratory, Connecticut Department of Public Health, Rocky Hill, CT 06067, USA
6
Arizona Department of Health Services, Office of Newborn Screening, Phoenix, AZ 85007, USA
7
Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
*
Author to whom correspondence should be addressed.
Int. J. Neonatal Screen. 2020, 6(3), 75; https://doi.org/10.3390/ijns6030075
Received: 7 August 2020 / Revised: 3 September 2020 / Accepted: 12 September 2020 / Published: 17 September 2020
(This article belongs to the Special Issue Newborn Screening: Promoting Quality to Optimise Benefit and Reduce Harm)
View Full-Text Download PDF
Browse Figures

Abstract

Newborn screening (NBS) laboratories cannot accurately compare mass spectrometry-derived results and cutoff values due to differences in testing methodologies. The objective of this study was to assess harmonization of laboratory proficiency test (PT) results using quality control (QC) data. Newborn Screening Quality Assurance Program (NSQAP) QC and PT data reported from 302 laboratories in 2019 were used to compare results among laboratories. QC materials were provided as dried blood spot cards which included a base pool and the base pool enriched with specific concentrations of metabolites in a linear range. QC data reported by laboratories were regressed on QC data reported by the Centers for Disease Control and Prevention (CDC), and laboratory’s regression parameters were used to harmonize their PT result. In general, harmonization tended to reduce overall variation in PT data across laboratories. The metabolites glutarylcarnitine (C5DC), tyrosine, and phenylalanine were displayed to highlight inter- and intra-method variability in NBS results. Several limitations were identified using retrospective data for harmonization, and future studies will address these limitations to further assess feasibility of using NSQAP QC data to harmonize PT data. Harmonizing NBS data using common QC materials appears promising to aid result comparison between laboratories. View Full-Text
Keywords: mass spectrometry; normalization; newborn screening; proficiency testing; metabolite mass spectrometry; normalization; newborn screening; proficiency testing; metabolite
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Pickens, C.A.; Sternberg, M.; Seeterlin, M.; De Jesús, V.R.; Morrissey, M.; Manning, A.; Bhakta, S.; Held, P.K.; Mei, J.; Cuthbert, C.; Petritis, K. Harmonizing Newborn Screening Laboratory Proficiency Test Results Using the CDC NSQAP Reference Materials. Int. J. Neonatal Screen. 2020, 6, 75. https://doi.org/10.3390/ijns6030075

AMA Style

Pickens CA, Sternberg M, Seeterlin M, De Jesús VR, Morrissey M, Manning A, Bhakta S, Held PK, Mei J, Cuthbert C, Petritis K. Harmonizing Newborn Screening Laboratory Proficiency Test Results Using the CDC NSQAP Reference Materials. International Journal of Neonatal Screening. 2020; 6(3):75. https://doi.org/10.3390/ijns6030075

Chicago/Turabian Style

Pickens, Charles A., Maya Sternberg, Mary Seeterlin, Víctor R. De Jesús, Mark Morrissey, Adrienne Manning, Sonal Bhakta, Patrice K. Held, Joanne Mei, Carla Cuthbert, and Konstantinos Petritis. 2020. "Harmonizing Newborn Screening Laboratory Proficiency Test Results Using the CDC NSQAP Reference Materials" International Journal of Neonatal Screening 6, no. 3: 75. https://doi.org/10.3390/ijns6030075

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Back to TopTop