Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis
Abstract
:1. Introduction
2. Case Description
2.1. Initial Diagnostic Workup
2.2. Surgical Intervention and Initial Outcomes
2.3. Tumor Recurrence and Further Management
2.4. Second Surgical Intervention and Postoperative Course
2.5. Long-Term Follow-Up and Disease Progression
- 1.
- A hypertrophic scar on the left thigh (from flap harvesting) (Figure 6A);
- 2.
- A thoraco-abdominal scar from the second surgical resection (Figure 6B).
2.6. Clinical Implications
3. Discussions
3.1. Diagnosis and Imaging Characteristics
3.2. Molecular Aspects and Prognostic Markers
3.3. Management Strategies: Surgery vs. Conservative Approaches
3.4. The Role of Watch-and-Wait in Desmoid Tumors
3.5. Radiotherapy as an Alternative or Adjuvant Treatment
3.6. Systemic Therapy and Locoregional Treatments
3.7. Final Considerations and Clinical Lessons
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Acronyms and Abbreviations
CIN III | cervical intraepithelial neoplasia |
AP/LL/CC | antero-posterior/latero-lateral/cranio-caudal |
CT | contrast tomography |
MRI | magnetic resonance imaging |
VEGF | vascular endothelial growth factor |
APC | adenomatous polyposis coli |
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Perné, M.-G.; Alexescu, T.-G.; Vlad, C.-V.; Milaciu, M.-V.; Leach, N.-V.; Togănel, R.-D.; Petre, G.-E.; Șimon, I.; Zolog, V.; Răzniceanu, V.; et al. Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis. J. Mind Med. Sci. 2025, 12, 13. https://doi.org/10.3390/jmms12010013
Perné M-G, Alexescu T-G, Vlad C-V, Milaciu M-V, Leach N-V, Togănel R-D, Petre G-E, Șimon I, Zolog V, Răzniceanu V, et al. Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis. Journal of Mind and Medical Sciences. 2025; 12(1):13. https://doi.org/10.3390/jmms12010013
Chicago/Turabian StylePerné, Mirela-Georgiana, Teodora-Gabriela Alexescu, Călin-Vasile Vlad, Mircea-Vasile Milaciu, Nicoleta-Valentina Leach, Răzvan-Dan Togănel, Gabriel-Emil Petre, Ioan Șimon, Vlad Zolog, Vlad Răzniceanu, and et al. 2025. "Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis" Journal of Mind and Medical Sciences 12, no. 1: 13. https://doi.org/10.3390/jmms12010013
APA StylePerné, M.-G., Alexescu, T.-G., Vlad, C.-V., Milaciu, M.-V., Leach, N.-V., Togănel, R.-D., Petre, G.-E., Șimon, I., Zolog, V., Răzniceanu, V., Bianca, S., Ciumărnean, L., & Orășan, O.-H. (2025). Desmoid Tumor Management Challenges: A Case Report and Literature Review on the Watch-and-Wait Approach in Recurrent Thoracic Fibromatosis. Journal of Mind and Medical Sciences, 12(1), 13. https://doi.org/10.3390/jmms12010013