The National Cancer Institute’s Co-Clinical Quantitative Imaging Research Resources for Precision Medicine in Preclinical and Clinical Settings

Round 1

Reviewer 1 Report

This is an interesting overview of an important research program.  In general the manuscript is well written but somewhat marred by numerous grammatic and word usage errors. 

On line 61 the author states that a repository for PDS and other related animal models was created. This needs explanation as an animal can not be placed into a repository.  

There is significant redundancy between the CIRP projects section and the Advance and emerging methods section.  

Author Response

see attachment for the responses to Review 1.

Author Response File: Author Response.docx

Reviewer 2 Report

Dear author,

congratulations to a nice work.

Minor details: 

I think it would be nice with a list of abbreviations; since there are alot of them.

I think you could look it over to add some references on places where you write important things, just an example here: such as what is required in future development about CIRP. Such as in the final section of the discussion; data format conversion, information integration from -omics...etc

That is, issues that need to be strengthen. 

In page 4, there is a lot of Figure text; can pleaase you either shorten it or move some of it to the main text?

In page 5, the Table 1 looks kind of unprofessional with all the cells; the Table headings text font sizes should be larger; the vertical lines may not be necessary...

First Column in the Table; reads 'Cancers' ; can you find a better way to express the essence of the column in the Column header; (something like 'the anatomy/organ where the cancer appear')? I mean, there are many different types of cancers for the breast....

Can you pls add some images of interest of the valuable tomographic imaging techniques, with regards to the text section on page 6 ('the CIRP Web Accessible Resources'). Overall, there is just a lot of text with no image illustrations...or very simple schematic figures. It would be easier to read with some illustrative figures. Thanks.

Author Response

See attached for responses to Reviewer 2.

Author Response File: Author Response.docx