Allergic Contact Dermatitis in Athletes: A Narrative Review of Allergens, Diagnosis, and Management

Abstract

Allergic contact dermatitis (ACD) is an increasingly common condition among athletes due to repeated exposure to sport-specific equipment, environmental allergens, and topical products. Sweating and repetitive cutaneous trauma facilitate allergen penetration. Rubber accelerators, metals, textile dyes, adhesives, synthetic resins, and topical medications represent the principal allergen categories implicated in sports-related ACD. This narrative review synthesizes the current literature on the epidemiology, pathophysiology, allergen profiles, and sport-specific exposure patterns of ACD in athletes, while outlining the essential principles of clinical recognition and targeted allergen avoidance.

1. Introduction

The skin is the body’s first line of defense against environmental allergens. Unfortunately, when the skin’s immunological defenses misfire, allergic contact dermatitis (ACD) may ensue. ACD is an inflammatory condition characterized by pruritic, eczematous eruptions and is mediated by a delayed, type IV hypersensitivity reaction, with presentation often hours to days after exposure [1,2]. In athletes, the skin barrier is subjected to both physical and chemical stresses that can lead to high rates of dermatologic conditions, including significantly higher rates of ACD [1,3,4]. Prolonged and repetitive contact with equipment and environmental exposures may lead to higher rates of ACD in athletes [1,3,5]. In athletes, frequent contact with sports equipment can be considered a form of occupational exposure, with ACD being the most prevalent occupational skin disease [5,6]. Herein, we offer a comprehensive overview of ACD in athletes which builds upon existing literature by providing an updated synthesis of current sports-related allergens up to 2026, accounting for any shifts in sportswear materials.

2. Methodology

This narrative review was conducted across two databases, Pubmed and Embase, for articles published through May 2026. Searches were conducted using keywords such as “allergic contact dermatitis”, athletes, athletics, sport, and names of individual sports (e.g., cycling, swimming, soccer). The search was limited to English-language, peer-reviewed articles. Abstracts were screened for relevance to sports-related ACD. Articles were then included if they contained relevant epidemiological details and/or confirmed patch-test results in athletic populations. Generative artificial intelligence tools were used to assist with the generation of figures, including ChatGPT (GPT-5.5) for figure development support. All AI-generated outputs were reviewed, verified, and edited by the authors.

3. Pathophysiology and Risk Factors

ACD develops through a two-phase immunologic process. In the sensitization phase, a hapten, a chemically reactive molecule, comes into contact with the epidermis [7,8]. Dendritic cells present the hapten to T lymphocytes in regional lymph nodes, generating allergen-specific memory T cells [7,8]. In the elicitation phase, the memory T cells initiate an inflammatory response at the site of contact, where dermatitis begins to form roughly 24–72 h after the next exposure event [7,8,9]. The molecular events involved in the sensitization and elicitation phases are shown in Figure 1.

Athletes may face an increased risk of sensitization due to multiple factors that can impair the skin barrier. These factors include sports equipment, topical medications the athletes may use, and both indoor and outdoor environmental exposures [6,9,10,11,12]. Exercise can lead to pH changes in the skin and increased sweat production, both of which can disrupt the normal skin barrier function and leach additional allergens onto the skin [5]. Additionally, tighter-fitting uniforms can lead to barrier disruption as well as increased time in contact with allergens [5]. Different sports present distinct allergen exposure patterns that influence both the type and distribution of ACD lesions. Common allergen exposures based on sport type are listed in

Table 1. Sport-specific allergens.

Sport/Activity	Source of Exposure	Common Allergens/Irritants	Source
Bowling, Trapshooting, Billiards	Hard balls, clubs and cues	Epoxy resins	[3,13]
	Grip enhancers/environment	Colophonium (rosin), TMTD on lawn greens	[3,13]
	Shotguns	Friction from the wood stock, (R)-4-methoxydalbergione and obtusaquinone	[3,14]
Cycling	Athletic/tennis shoes	Acetophenone azine, Ethylbutyl thiourea, Mercaptobenzothiazole, Dibenzothiazole disulfide, Dithiocarbamates	[3,13]
	Clothing	Friction from hard-fibered shirts	[3]
	Topical treatments/creams	Benzocaine, Lanolin, Arnica, Eucalyptus, Palmitoyl hydrolysed milk, Palmitoyl collagen amino acids Lipacide-cas	[3,5]
	Bicycle handles/parts	Vulcanization accelerators, Thiurams, Mercaptobenzothiazole, Paraphenylenediamine, Potassium dichromate, Yellow dispersion	[3,5,13]
	Metal gear	Nickel	[5]
Weightlifting, Gym Sports, Judo, Fencing	Metal weights and bars	Nickel, Palladium	[3,13,15]
	Grip enhancers	Colophony, Chalk	[3,5,15]
	Mats/carpets	Sudan IV red dye	[3,15]
Ice/Winter Sports	Equipment	Aluminum, Epoxy resins, Cobalt, Formaldehyde, Fiberglass, Acetophenone azine	[3,13,16,17]
	Helmets and padding	Preservatives (isothiazolinones)	[11,13]
	Ski boots	1,6-hexanediol diacrylate (1,6 HDDA)	[18]
Racquet, Golf, Equestrian Sports	Tanned leather	Chromium, Cobalt	[13]
	Racquets	Isophorone diamine, Epoxy resin	[3]
	Clothing and guards	Rubber accelerators, PTBP-FR, Diphenylthiourea (splints), Friction	[3]
	Sprays	Ethyl chloride anesthetic spray	[3]
Running, Jogging, Walking	Athletic/tennis shoes	Acetophenone azine, Ethylbutyl thiourea, Mercaptobenzothiazole, Dibenzothiazole disulfide, Dithiocarbamates	[3,13]
	Clothing	Friction from hard-fibered shirts	[3]
	Topical treatments/creams	Benzocaine, lanolin, arnica, eucalyptus, palmitoyl hydrolysed milk, palmitoyl collagen amino acids, lipacide-cas	[3,5]
Team and Field Sports (Football, Soccer, Basketball, Baseball, Volleyball)	Protective gear (shin pads) and apparel	Acetophenone azine, urea formaldehyde resin, ethylene vinyl acetate	[3,12,13,19]
	Ball handling	Vulcanization accelerators, thiuram, mercaptobenzothiazole, IPPD, PTBP, friction	[3,13,20,21]
	Field/environment	Alkaline lime component from field markings (cement burns), photoactive substances from field plants	[3]
	Topical treatments	Benzocaine, lanolin	[5]
Swimming, Diving, Water Sports	Wet-suits/neoprene	Thiourams, latex, thioureas, mercaptobenzothiazole, nickel dyes, PTBP-FR, ethylbutylthiourea, diethylthiourea, dibutylthiourea, diphenylthiourea, nickel, Tego 103G disinfectant	[3,5,15]
	Goggles and diving masks	Sunscreens (benzophenone), benzoyl peroxide, phenol-formaldehyde resin, black foam rubber, IPPD, thioureas	[3,13,22,23]
	Swim caps, ear plugs and fins	Thiourams, latex, IPPD, CPPD, DPPD, mercaptobenzothiazole, dibutylthiourea, diethylthiourea	[3,5]
	Pool and spa water	Disinfectants containing chlorine, bromine, persulfates, di-halo chlorinated compounds, and halobrome	[3,13,15,24]
	Swimsuits	Biocides (Quats)	[13]
	Sailing/windsurfing gear	Thiourams, nickel, latex, CPPD, IPPD, DPPD	[3]
	Environment and physical factors	Seaweed toxins, Red Sea coral, cold water, rocks, sand, saltwater friction, and unshaven beard friction	[3]
General/Protected Sports (All)	Sports tape and medical adhesives	Colophony (rosin), formaldehyde resins, PTBP-FR, tincture of benzoin	[3,5,13,15]
	Glues and polymers in pads and shoes	Para-tert-butylphenol formaldehyde resin, ethylene vinyl acetate	[15]
	Sunscreen	Benzophenone-3/Oxybenzone and Octocrylene	[25,26]
	Uniform dyes	p-aminoazobenzene, p-phenylenediamine, Disperse Orange 3, Disperse Blue 124, and Disperse Blue 106	[27]

TMTD: tetramethylthiuram disulfide, PTBP-FR: P-tert-butylphenol-formaldehyde resin, IPPD: N-isopropyl-N′-phenyl-p-phenylenediamine, PTBP: para-tertiary butylphenol formaldehyde resin, CPPD: N-cyclohexyl-N′-phenyl-p-phenylenediamine, DPPD: N,N′-diphenyl-p-phenylenediamine.

, described below, and visually represented in Figure 2.

4. Sport-Specific Allergens

4.1. Bowling, Trapshooting and Billiards

Bowling balls and billiard cues often contain sensitizing epoxy resins, while athletes using shotguns may be sensitized from wood stock, wood resins, and various metals which may include nickel, chromium, cobalt, copper, and lead [3,13,14].

4.2. Cycling

Cyclists endure repeated contact with rubber and metal components on their bikes, as well as friction from their gear. Bicycle handlebars and grips are a major source of exposure to various allergens such as vulcanization accelerators, e.g., thiurams, mercaptobenzothiazole and carbamates, paraphenylenediamine, potassium dichromate, and dyes [3,5,13]. Metal gear components can also lead to nickel sensitization [5]. Additionally, cyclists may manage muscle fatigue with anti-inflammatory creams containing benzocaine, arnica, or eucalyptus, which frequently trigger ACD on the legs or trunk [3,5].

4.3. Gym Sports, Weightlifting, Judo and Fencing

Athletes in these indoor sports face unique exposures based on the equipment they handle. Weightlifters may be exposed to nickel and palladium through repeated contact with metal weight bars and dumbbells [3,13,15]. Grip enhancers such as rosins and chalk are widely used in fencing and weightlifting, and can contain sensitizers such as colophony [3,5,15]. Other unique indoor exposures include Sudan IV red dye found in judo carpets and mats [3,15]. Some mat cleaners may have isothiazolinone derivatives which can lead to ACD [1].

4.4. Winter Sports (Ice Skaters, Hockey Players, Speed Skaters, Skiing and Others)

Ice sport participants can be exposed to various allergens from skates, costumes/uniforms, or protective padding. The boot of the ice skates can include leather, leather dyes, and various adhesives which are common allergens [28]. Hockey masks and pads can expose athletes to epoxy resins, acetophenone azine and neoprene, which can also lead to ACD, all of which can lead to lesions appearing on the face, foot and lower legs [16,17,28]. Some ski boots have also been found to contain 1,6-hexanediol diacrylate (1,6 HDDA), which can lead to ACD on the feet [18].

4.5. Racquet Sports, Golf, and Equestrian Sports

Grips, racquets, and specialized gloves can lead to ACD in these athletes. The resins found in the racquets and golf clubs are often found to cause ACD [3]. Golfers and horseback riders frequently wear tanned leather gloves or boots that can contain chromium and cobalt which can also lead to ACD [13]. Equestrian athletes are also exposed to metal components (e.g., stirrups, bits), which may contain nickel.

4.6. Running and Track Sports

Runners and track athletes are primarily affected by their footwear, clothing, and topical treatments. Athletic shoes are a common source of ACD due to the glues and foams that may be used in the shoe, as well as rubber accelerators such as acetophenone azine, ethylbutyl thiourea, mercaptobenzothiazole, and disulfide [3,5]. Like many athletes, runners frequently use topical treatments containing benzocaine and lanolin that can lead to skin sensitization [5].

4.7. Team and Field Sports (Football, Soccer, Basketball, Baseball, Softball, Cricket, Volleyball)

Athletes in field and team sports face primary exposures from their footwear, protective padding, adhesives, and the playing environment. Shin guards, sports socks, and athletic shoes frequently contain different resins, including rubber accelerators and adhesives such as acetophenone azine, ethylene vinyl acetate and urea-formaldehyde resins [3,13,19]. Athletic apparel and equipment can then lead to ACD in sports such as baseball, softball, and cricket [12]. Ball handlers in basketball and baseball are uniquely exposed to other allergens on the balls and/or gloves, such as vulcanization accelerators, e.g., thiurams, para-tert-butylphenol formaldehyde resin (PTBP-FR) and mercaptobenzothiazole [3,13,20,21]. Additionally, the use of sports tape and medical adhesives in these high-impact sports expose athletes to rosin, benzoin, and formaldehyde resins [3,5,15]. Finally, outdoor athletes are likely exposed to additional environmental allergens dependent on where they play their sports. Turf may contain mercaptobenzothiazole and benzothiazole, rubber accelerators that can lead to sensitization [5]. Basketball courts can have various stains and sealants that can lead to ACD, including isocyanates, phenol-formaldehyde resins, colophonium rosin, balsam of Peru, and epoxy resins [29,30,31,32]. Sports such as volleyball can prompt exposure to the same allergens seen in shoes and metal, such as acetophenone azine, ethylbutyl thiourea, mercaptobenzothiazole, dibenzothiazole, and nickel [3,5,13].

4.8. Water Sports (Swimmers, Divers, Sailors, Windsurfers)

Aquatic athletes are exposed to allergens through their protective gear, accessories, and the water environment itself. Wetsuits, earplugs, fins, and swim caps may cause ACD due to prolonged skin contact with neoprene and rubber additives [13,15,28]. Goggles and diving masks may include benzoyl peroxide, phenol-formaldehyde resin, and black foam rubber [3,15,22,23]. Additionally, the water environment can act as a chemical trigger; swimming pools and spas contain disinfectants such as chlorine, bromine, persulfates, and others which can lead to ACD [3,15,24]. Sailors and windsurfers may also react to environmental biological toxins from seaweed or coral, as well as friction from salt water and sand [3].

4.9. General Exposures

In addition to sports-related allergens, some exposure risks are common across sports, such as lawn greens, grip enhancers, sports tape, and sunscreens. Grip enhancers/rosins frequently expose athletes to colophony (rosin) and tetramethylthiuram disulfide (TMTD) [3,13]. Frequent applications of sports tape and medical adhesives bring athletes into contact with colophony, formaldehyde resins, PTBP-FR, and tincture of benzoin [3,5,13,15]. Glues and polymers found in athletic pads and shoes commonly contain PTBP-FR and ethylene vinyl acetate [13]. Outdoor athletes frequently utilize sunscreens containing allergens such as benzophenone-3/oxybenzone and Octocrylene [25,26]. These can lead to photoallergic contact dermatitis [25,26].

Uniforms may also lead to ACD, commonly elicited from blue or black textiles with tight skin contact, such as compression shorts, sports bras, cycling jerseys, and dark-colored team uniforms [27]. These may contain specific textile allergens including p-aminoazobenzene, p-phenylenediamine (PPD), Disperse Orange 3, Disperse Blue 124, and Disperse Blue 106 [27].

5. Clinical Presentation

ACD in athletes can present as acute or chronic dermatitis. Acute ACD often presents as pruritic, erythematous, oozing and/or crusted plaques, possibly with vesiculation or bullae [33]. Chronic ACD can present with psoriasiform changes and lichenification [33]. ACD in athletes with pre-existing atopic dermatitis (AD) may present with a phenotype similar to AD, but occur in distinct patterns and distributions that may not map to typical AD distribution [34]. Examining the distribution patterns of the lesions and knowing the sport the athlete plays may provide insight about what allergen is causing the ACD.

6. Diagnosis, Management, and Prevention

ACD must be distinguished from several conditions that may present similarly in athletes. These include irritant contact dermatitis, atopic dermatitis (AD), psoriasis, tinea pedis, and others [35]. The diagnosis is often made based on a meticulous, sport-specific history of possible exposures and the physical examination findings, which can include a geometric or well-demarcated eczematous pattern corresponding to the site of gear or product contact [35,36]. If the allergen is unknown, then patch testing may be indicated to confirm both the diagnosis and the source of the ACD [35]. A standard screening series (e.g., American Contact Dermatitis Society core series) should be supplemented with sport-specific materials and the patient’s own products, as some relevant allergens may be missed by screening series alone [37].

For management, adjustments can be made to equipment, education on allergen avoidance should be provided, and return-to-sport protocols should be discussed with the athlete. For allergen avoidance, the primary strategy is substituting gear with alternative equipment that does not contain sensitizing materials. This method of proactive substitution significantly reduces the likelihood of developing or exacerbating ACD in the future. However, if the athlete is unable to avoid the sensitizing agent entirely (e.g., due to specialized or mandated regulatory equipment), they may be able to use personal protective equipment or physical barriers (such as specialized clothing, liners, or barrier creams) against the agent-containing equipment.

When avoidance and barriers fail, pharmacological intervention may become necessary. Topical or oral corticosteroids may be used for symptomatic relief dependent on the severity of the reaction [38]. Additionally, medications such as antihistamines, topical calcineurin inhibitors, methotrexate, azathioprine, mycophenolate mofetil, and phosphodiesterase 4 inhibitors have been used in the treatment of ACD [38]. However, when managing competitive athletes, the clinician must cross-reference all systemic and immunomodulatory medications with the World Anti-Doping Agency (WADA) Prohibited List to ensure compliance or arrange for a Therapeutic Use Exemption (TUE) [39]. Finally, a structured return-to-sport protocol should dictate that the athlete only returns to full training intensity once inflammation and barrier disruption have completely resolved, as active sweating and friction may delay healing.

7. Conclusions

Allergic contact dermatitis is a common skin condition in athletes, driven by repeated exposure to sport-specific equipment, environmental substances, and topical products. While the precise incidence and prevalence of ACD in athletes remains largely unquantified due to a lack of large-scale epidemiological cohorts, available data suggest a heightened risk due to the athletic environment. Since symptoms of ACD may impair comfort, performance, and participation, early recognition and treatment are essential. Careful history-taking, attention to lesion distribution, and patch testing when indicated can help identify relevant allergens. Management should focus on allergen avoidance, treatment of inflammation, and modification of equipment or exposures. Greater awareness among clinicians, trainers, and athletes can improve prevention strategies and allow safer continuation of sporting activities.